PIK3CA 突变影响因素对鳞状细胞肺癌预后的影响

Influence of PIK3CA mutation affecting factors on prognosis of squamous cell lung carcinoma

摘要:

目的 探讨PIK 3CA 基因突变与鳞状细胞肺癌患者临床病理特征及预后的关系。方法 选取 2013 年2 月-2016 年2 月于上海长海医院收治的鳞状细胞肺癌患者81 例，同时选取癌旁组织（≥ 5 cm）作为 对照组，检测样本PIK 3CA 突变情况，以及随访患者生存情况。结果 肺癌组织PIK 3CA 基因突变率高于癌旁 组织（P <0.05）；不同性别、年龄、分化程度、TNM 期及有无淋巴结转移患者PIK 3CA 基因突变率比较差异无 统计学意义（P >0.05）；PIK 3CA 基因突变组患者中位生存期与PIK 3CA 基因未突变组比较差异有统计学意义 （P <0.05）；分化程度、TNM 分期及PIK 3CA 基因突变是患者预后的影响因素（P <0.05）。结论 鳞状细胞肺癌 组织PIK 3CA 基因突变高于癌旁组织，但与病理特征无明显关系，PIK 3CA 基因突变患者预后较未突变者差。

Abstract:

Objective To investigate the relationships of mutation of PIK3CA gene with the clinicopathological features and prognosis of squamous cell carcinoma of the lungs. Methods From February 2013 to February 2016, 81 patients with lung squamous cell carcinomas were treated in our hospital, and the adjacent tissues ( ≥ 5cm) were taken as controls. PIK3CA mutations were detected and the survival of the patients were followed up. Results The mutation rate of PIK3CA gene in the lung carcinoma tissues was 19.51%, which was significantly higher than 0.00% in the adjacent tissues, and the difference was statistically significant (P < 0.05). There were no significant differences in the rate of PIK2CA gene mutation among the patients of different sex, age, differentiation degree, TNM stage and lymph node metastasis (P > 0.05). The median survival time of the PIK3CA mutation group was 14 m, significantly shorter than 26 m of the PIK3CA gene non-mutation group (P < 0.05). Cox regression analysis showed that differentiation degree, TNM stage and PIK3CA gene mutation were the factors influencing the prognosis of the patients (P < 0.05). Conclusions The mutation rate of PIK3CA gene in lung squamous cell carcinoma is significantly higher than that in paracancerous tissues, but it is not related to pathological features. The prognosis of the patients with PIK3CA gene mutation is worse than that of the patients without PIK3CA mutation.