COPD 稳定期患者血清Galectin-3、 VAP-1 水平及其临床意义

Clinical significance of serum galectin-3 and VAP-1 levels in patients with stable chronic obstructive pulmonary disease

摘要:

目的 探究慢性阻塞性肺疾病（COPD）稳定期患者血清半乳糖凝集素-3（Galectin-3）、血 管黏附蛋白-1（VAP-1）的表达水平及其临床意义。方法 选取2016 年1 月-2017 年12 月在该院就诊 的100 例COPD 稳定期患者作为COPD 组，同期选取100 例健康志愿者作为对照组。比较两组患者的血清 Galectin-3、VAP-1 水平，以及肺功能指标、炎症因子水平、慢性阻塞性肺病评估测试（CAT）评分的差异。 分析血清Galectin-3 或VAP-1 水平与肺功能指标、炎症因子水平、CAT 评分的关系。分析血清Galectin-3 水平与血清VAP-1 水平的相关性。结果 COPD 组患者的血清Galectin-3、VAP-1 水平高于对照组（P <0.05）。 COPD 组患者的用力肺活量（FVC）、1 s 用力呼气容积（FEV1）及FEV1/FVC 水平低于对照组（P <0.05）。 COPD 组患者的白介素-6、超敏C 反应蛋白、肿瘤坏死因子-α 高于对照组（P <0.05）。COPD 组患 者CAT 评分高于对照组（P <0.05）。Spearman 相关分析结果显示，COPD 稳定期患者的血清Galectin-3、 VAP-1 水平与患者肺功能指标呈负相关（P <0.05），与炎症因子水平、CAT 评分呈正相关（P <0.05）；血清 Galectin-3 与VAP-1 水平呈正相关（P <0.05）。结论 COPD 稳定期患者的血清Galectin-3、VAP-1 水平升高， 且与肺功能、炎症因子水平及生活质量相关。

Abstract:

Objective To detect the expression levels of serum galectin-3 and vascular adhesion protein-1 (VAP-1) in patients with chronic obstructive pulmonary disease (COPD), and to explore its clinical significance. Methods From January 2016 to December 2017, 100 patients with stable COPD were selected as the stable COPD group, and 100 healthy volunteers were selected as the control group. The differences in serum galectin-3 level, serum VAP-1 level, pulmonary function indexes, inflammatory cytokines levels and the COPD Assessment Test (CAT) score were compared between the two groups. The correlations of serum galectin-3 and VAP-1 levels with pulmonary function indexes, inflammatory cytokines levels and the CAT score were analyzed,and the correlation between serum galectin-3 level and serum VAP-1 level was also analyzed. Results The serum galectin-3 and VAP-1 levels in the stable COPD group were significantly higher than those in the control group (P < 0.05). The pulmonary function indexes in the stable COPD group including forced vital capacity (FVC), forced expiratory volume in one second (FEV1) and FEV1/FVC were significantly lower than those in the control group (P < 0.05). The inflammatory cytokines in the stable COPD group including IL-6, hs-CRP and TNF-α were significantly higher than those in the control group (P < 0.05). The CAT score in the stable COPD group was higher than that in the control group (P < 0.05). The serum galectin-3 and VAP-1 levels in the stable COPD group were negatively correlated with the pulmonary function indexes (P < 0.05), but positively correlated with the inflammatory cytokines and the CAT score (P < 0.05). There was a positive correlation between the serum galectin-3 and VAP-1 levels (P < 0.05). Conclusions Serum levels of galectin-3 and VAP-1 in patients with stable COPD are increased, and closely related to pulmonary function, inflammatory factors and the quality of life.