抑郁症患者血清TNF-α、IL-8、ICAM-1、 NF-κB 水平及其意义

Serum levels of TNF-α, IL-8, ICAM-1 and NF-κB and their significance in patients with depression

摘要:

目的 探讨抑郁症患者血清肿瘤坏死因子-α（TNF-α）、白细胞介素-8（IL-8）、细胞间 黏附分子（ICAM-1）、核因子-κB（NF-κB）水平及其意义。方法 选择2016 年1 月-2017 年12 月在 该院就诊的抑郁症患者80 例作为抑郁症组，健康体检者80 例作为对照组。采用酶联免疫吸附实验测定血 清TNF-α、IL-8、ICAM-1、NF-κB 水平。采用汉密尔顿抑郁量表（HAMD）评定患者的抑郁情绪。 结果 抑郁症组患者血清TNF-α、IL-8、ICAM-1、NF-κB 水平和HAMD 评分高于对照组（P <0.05）； 治疗后血清TNF-α、IL-8、ICAM-1、NF-κB 水平和HAMD 评分低于治疗前（P <0.05）。抑郁症患者血 清TNF-α、IL-8、ICAM-1、NF-κB 水平与HAMD 评分呈正相关（P <0.05）。抑郁症患者血清TNF-α、 IL-8、ICAM-1 与NF-κB 水平呈负相关（P <0.05）。结论 抑郁症患者血清TNF-α、IL-8、ICAM-1、 NF-κB 水平升高，炎症反应参与抑郁症的发病过程。

Abstract:

Objective To investigate the serum levels of tumor necrosis factor-α (TNF-α), interleukin 8 (IL- 8), intercellular adhesion molecule 1 (ICAM-1) and nuclear factor-κB (NF-κB) in the patients with depression and their significance. Methods Eighty patients with depression treated in Huzhou Third People’s Hospital from January 2016 to December 2017 were selected as the depression group and 80 healthy persons were selected as the control group. Serum TNF-α, IL-8, ICAM-1 and NF-κB levels were measured by enzyme-linked immunosorbent assay. Patients’ depressive mood was assessed using the Hamilton Depression Scale (HAMD). Results The serum levels of TNF-α, IL-8, ICAM-1and NF-κB, and HAMD scores in the depression group were higher than those in the control group (P < 0.05). The serum TNF-α, IL-8, ICAM-1and NF-κB levels and HAMD scores after treatment were lower than those before treatment in the depression group (P < 0.05). The serum TNF-α, IL-8, ICAM-1 and NF-κB levels were positively correlated with HAMD scores in the patients with depression (P < 0.05). The levels of serum TNF-α, IL-8 and ICAM-1 in the patients with depression were negatively correlated with the level of NF-κB (P < 0.05). Conclusions The serum levels of TNF-α, IL-8, ICAM-1 and NF-κB are elevated in the patients with depression. The inflammatory responses are involved in the pathogenesis of depression.