醋酸甲地孕酮改善中晚期结直肠癌患者化疗后 骨髓抑制及生活质量的应用价值

Effect of mgestrol acetate on improving chemotherapy-induced myelosuppression and quality of life in patients with advanced colorectal cancer

摘要:

目的 探讨醋酸甲地孕酮（MA）改善中晚期结直肠癌患者化疗后骨髓抑制和改善患者生活质量 的应用价值。方法 将98 例中晚期结直肠癌患者随机分为实验组和对照组，每组各49 例。实验组应用化疗 加口服MA 分散片；对照组仅进行化疗。两组均进行2 周期XELOX 标准方案化疗，观察并分析两组骨髓抑 制、KPS 评分、体重及生活质量的变化情况。结果 两组骨髓抑制、KPS 评分及体重比较，差异有统计学意义 （P <0.05），实验组较对照组生活质量改善（P <0.05）。结论 MA 能有效改善中晚期结直肠癌患者化疗后骨髓 抑制，提高生活质量、且不增加毒副作用，值得进一步推广。

Abstract:

Objective To evaluate the clinical application of Megestrol Acetate (MA) in improving chemotherapy-induced myelosuppression and quality of life in advanced colorectal cancer patients. Methods Ninetyeight cases of colorectal cancer were involved and randomly divided into two groups. All patients received standard chemotherapy (XELOX). A total of 49 patients in observation group received additional MA. Myelosuppression and quality of life were evaluated after 2 cycles of standard chemotherapy. Results MA exerted a significant improvement in chemotherapy-induced myelosuppression, KPS score, body weight, and quality of life (P < 0.05). Conclusion MA can effectively improve bone marrow suppression and quality of life in patients with advanced colorectal cancer after chemotherapy.