术前FOLFOX6 方案联合腹腔镜胃癌根治术 对进展期胃癌患者Lgr5、Oct4 表达的影响

Effect of preoperative FOLFOX6 adjuvant chemotherapy and laparoscopic radical gastrectomy on expressions of Lgr5 and Oct4 in patients with advanced gastric cancer

摘要:

目的 探讨术前FOLFOX6 方案辅助化疗联合腹腔镜胃癌根治术对进展期胃癌患者Lgr5、Oct4 表达的影响。方法 选取2012 年3 月至2015 年3 月河南省中医院Ⅱ、Ⅲ期胃癌患者124 例，采用随机数字表 法分为对照组和实验组，各62 例。对照组患者接受胃癌根治术治疗，实验组患者接受术前FOLFOX6 方案辅 助化疗联合腹腔镜胃癌根治术治疗。评估治疗后两组患者的近期有效率和不良反应发生率；比较手术前后两 组患者胃黏膜组织中Lgr5 和Oct4 表达情况。结果 实验组的治疗有效率高于对照组（P <0.05）；两组患者在 白细胞减少、肝肾功能损害、腹泻及肠梗阻这几种并发症的发生率上差异无统计学意义（P >0.05）；治疗后 两组患者Lgr5 和Oct4 表达均降低（P <0.05），但治疗后实验组Lgr5 和Oct4 表达低于对照组（P <0.05）。结 论 术前FOLFOX6 方案辅助化疗联合腹腔镜胃癌根治术治疗进展期胃癌患者效果优异，治疗安全性好，可有 效降低胃癌组织Lgr5 和Oct4 表达。

Abstract:

Objective To investigate the effect of preoperative FOLFOX6 adjuvant chemotherapy combined with laparoscopic radical gastrectomy on the expressions of Lgr5 and Oct4 in patients with advanced gastric cancer. Methods Totally 124 cases of stage II and Ⅲ gastric carcinomas were examined and treated in Henan Provincial Hospital of Traditional Chinese Medicine from March 2012 to March 2015. These cases were randomly divided into two groups. The patients in the control group received radical gastrectomy, and the patients in the experimental group received preoperative FOLFOX6 adjuvant chemotherapy and laparoscopic radical gastrectomy. The short-term efficacy and the incidence of adverse reactions of the two groups were evaluated after treatment, and the expressions of Lgr5 and Oct4 in the gastric mucosa before and after treatment were compared between the two groups. Results The treatment efficiency of the experimental group was significantly higher than that of the control group (P < 0.05). There was no significant difference in the incidence of white blood cell reduction, liver and renal function damage, diarrhea, or intestinal obstruction between the two groups (P > 0.05). After treatment, the expressions of Lgr5 and Oct4 were significantly reduced in the two groups (P < 0.05), moreover, the expressions of Lgr5 and Oct4 in the experimental group were significantly lower than those in the control group (P < 0.05). Conclusions The effect of preoperative FOLFOX6 adjuvant chemotherapy combined with laparoscopic radical gastrectomy is significant for advanced gastric cancer. The treatment is safe and can effectively reduce the expressions of Lgr5 and Oct4 in the cancerous tissues.