肝素酶、碱性成纤维细胞生长因子在非小细胞 肺癌中的表达及与预后的关系

Expressions of heparinase and bFGF in NSCLC tissues and their correlations with lung cancer metastasis and prognosis

摘要:

目的 研究非小细胞肺癌（NSCLC）组织中肝素酶、碱性成纤维细胞生长因子（bFGF）的表达 情况，分析其与肺癌转移和预后的关系。方法 选取2012 年6 月—2014 年6 月河南省人民医院收治的48 例 NSCLC 患者作为研究对象，所有患者均行手术治疗，术中取肺癌组织样本作为观察组，取癌旁组织样本作为 对照组。观察肝素酶、bFGF 在两组样本中的表达情况，分析肝素酶、bFGF 表达与临床病理因素的关系。采用 Logistic 回归方程进行计算，探究NSCLC 患者肝素酶、bFGF 表达与转移和生存的关系。结果 观察组中肝素酶 阳性例数38 例（79.17%），bFGF 阳性例数37 例（77.08%）。对照组中肝素酶、bFGF 均为阴性表达，观察组肝素 酶、bFGF 阳性表达率与对照组比较差异有统计学意义（P <0.05）。肝素酶表达与NSCLC 患者病理分期、血管 浸润以及淋巴结转移有关；而bFGF 表达则与NSCLC 患者病理分期、分化程度、血管浸润及淋巴结转移有关。 随访NSCLC 患者3 年，生存患者26 例，生存率54.17%。死亡患者22 例，病死率45.83%。NSCLC 生存和死亡 患者在分化程度、血管浸润、淋巴结转移及bFGF 表达上差异有统计学意义（P <0.05）。将上述有差异因素带入 Logistic 回归方程分析发现，分化程度、血管浸润、淋巴结转移及bFGF 表达均是NSCLC 患者预后的影响因素。 结论 肝素酶、bFGF 与NSCLC 的转移、血管浸润等密切相关，与NSCLC 的预后也有明显关系。

Abstract:

Objective To analyze the clinical expressions of heparinase and basic fibroblast growth factor (bFGF) in the non-small cell lung cancer (NSCLC) tissues and their correlations with the lung cancer metastasis and prognosis. Methods Forty-eight NSCLC patients treated in Henan Provincial People’s Hospital from June 2012 to June 2014 were selected. During operation, the samples of lung cancer tissues were collected as the observation group, the samples of para-cancerous tissues were collected as the control group. The expressions of heparinase and bFGF were observed, their correlations with the clinical pathological characteristics were analyzed. Using logistic regression equation, the correlations of heparinase and bFGF expressions with the cancer metastasis and survival rate were analyzed. Results In the observation group, there were 38 heparinase-positive cases (79.17%) and 37 bFGFpositive cases (77.08%); in the control group, the heparinase and bFGF were negatively expressed, the differences were statistically significant between the two groups (P < 0.05). The heparinase expression was correlated with the NSCLC pathological staging, vascular invasion and lymphatic metastasis; the bFGF expression was correlated with the pathological staging, differentiation degree, vascular invasion and lymphatic metastasis. After 3 y of follow-up, 26 cases survived (54.17%) and 22 cases died (45.83%). The differentiation degree, vascular invasion, lymphatic metastasis and bFGF expression were significantly different between the survived cases and the dead cases (P < 0.05). The influencing factors of the prognosis included the differentiation degree, vascular invasion, lymphatic metastasis and bFGF expression. Conclusions The expressions of heparinase and bFGF are closely correlated with cancer metastasis and vascular invasion as well as the prognosis of NSCLC patients.