胸腺五肽对脓毒症致急性肾损伤患者 肾功能的影响

Effect of thymopentin on renal function in patients with sepsisinduced acute kedney injury

摘要:

目的 探究讨胸腺五肽对脓毒症引起的急性肾损伤患者肾脏的保护作用。方法 选取2015 年6 月— 2016 年12 月苏州大学附属第三医院脓毒症引发的急性肾损伤患者54 例，随机分为观察组和对照组，每组27 例。对照组患者给予常规治疗，观察组患者在常规治疗的基础上进行胸腺五肽10 mg 皮下注射，1 次/d，持续1 周。结果 两组患者在治疗前TNF-α、IL-10、CRP、PCT 浓度、T 淋巴细胞亚群CD3+、CD4+、CD8+ 细胞及 CD4+/CD8+ 的比值、血肌酐（Scr）和血尿素氮（BUN）浓度的比较差异无统计学意义（P >0.05）；治疗后两组 患者各指标比较差异有统计学意义（P <0.05），观察组患者的CD3+、CD4+、CD8+ 细胞及CD4+/CD8+ 的比值均 高于对照组；TNF-α、IL-10、CRP、PCT、Scr 和BUN 浓度均低于对照组。结论 胸腺五肽可提高和恢复脓 毒症患者的细胞免疫功能，对脓毒症引起的急性肾损伤患者肾脏起到保护作用，具有临床意义。

Abstract:

Objective To investigate the protective effect of thymopentin on renal function in patients with acute renal injury caused by sepsis. Methods Fifty-four cases of acute renal injury caused by sepsis in the Third Affiliated Hospital of Soochow University from June 2015 to December 2016 were selected, and randomly divided into an observation group and a control group, each group had 27 cases. The patients in the control group were treated with routine therapy. The patients in the observation group were subcutaneously injected with 10 mg thymopentin on the basis of routine therapy once a day for 1 week. Results Before treatment, there was no significant difference in tumor necrosis factor α (TNF-α), interleukin 10 (IL-10), C-reactive protein (CRP), procalcitonin (PCT), serum creatinine (Scr) or blood urea nitrogen (BUN) level, T-lymphocyte subset CD3+ cells, CD4+ cells or CD8+ cells or CD4+/CD8+ ratio between the two groups (P > 0.05). After treatment, CD3+, CD4+, CD8+ lymphocytes and CD4+ / CD8+ ratio in the observation group were significantly higher than those in the control group (P < 0.05); whereas the levels of TNF-α, IL-10, CRP and PCT, Scr and BUN in the observation group were significantly lower than those in the control group (P < 0.05). Conclusions Thymopentin can significantly restore and improve the cellular immune function of sepsis patients, and has important clinical effect of renal protection in patients with acute renal injury caused by sepsis.