内皮钙黏蛋白在子宫内膜异位症病变组织中的 表达及其临床意义

Role of VE-cad protein in patients with adenomyosis

摘要:

目的 探讨子宫腺肌病组织中血管内皮钙黏蛋白（VE-cad）表达变化及其临床意义。方法 选取 2016 年1 月—2017 年9 月北京市第一中西医结合医院病理科收集的40 例正常子宫内膜、平滑肌组织（正常组） 和80 例子内膜异位症病组织的子宫内膜、平滑肌组织（病例组）。采用免疫组织化学染色检测两组VE-cad 表 达情况，并分析其与临床病理因素的关系。结果 病例组异位内膜组织中VE-cad 阳性表达率高于病例组在位内 膜组织、正常组子宫内膜组织（P <0.05）；病例组子宫平滑肌组织中VE-cad 阳性表达率与正常组子宫平滑肌组 织中VE-cad 阳性表达率比较，差异无统计学意义（P >0.05）。子宫内膜异位症患者异位内膜组织中VE-cad 阴 性表达与年龄、病程有相关性（P <0.05），年龄越大、病程越长的患者异位内膜组织中VE-cad 阳性表达率越高； 子宫内膜异位症患者异位内膜组织中VE-cad 蛋白表达与患者是否应用止痛药无关（P >0.05）。结论 子宫内 膜异位症异位内膜组织中VE-cad 呈高表达，可能与子宫内膜异位症的发生有关，且与患者的年龄、病程有关。

Abstract:

Objective To investigate the expression of vascular endothelial cadherin (VE-cad) in adenomyosis and its clinical significance. Methods Endometrium and smooth muscle from 40 healthy uterus (normal group) and 80 cases of adenomyosis (case group) were collected from our hospital from January 2016 to September 2017. Expression of VE-cad was detected by immunohistochemistry. Relationship between VE-cad and clinical information was determined. Results Expression of VE-cad protein in ectopic endometrial tissues was increased significantly in case group compared with that in normal group and normal endometrial tissue in case group (P < 0.05). No difference of expression of VE-cad protein in uterine smooth muscle tissue of two groups was identified (P > 0.05). Expression of VE-cad protein was positively correlated with age and duration of the disease (P < 0.05). Expression of VEcad protein in ectopic endometrium was not correlated with administration of painkillers (P > 0.05). Conclusions Increased VE-cad protein expression in adenomyosis ectopic endometrial tissue may play a role in occurrence of adenomyosis, and it is positively associated with age and duration of the disease.