合并代谢综合征的膝骨关节炎患者临床特点分析

Clinical characteristics of knee osteoarthritis patients with metabolic syndrome

摘要:

目的 探讨合并代谢综合征的膝骨关节炎（KOA）患者临床特点。方法 选取2015 年1 月—2017 年9 月首都医科大学玄武医院风湿免疫科诊断的KOA 炎患者390 例，按有无合并代谢综合征（MS）分为 非代谢综合征组（非MS 组）239 例，膝骨关节炎合并代谢综合征组（合并MS 组）151 例，比较两组临床资 料。结果 两组患者的性别比较，差异有统计学意义（P <0.05）；合并MS 组BMI、腰围、舒张压（DBP）及 收缩压（SBP）均较非MS 组升高（P <0.05）。合并MS 组并发高血压、糖尿病、冠心病、脑血管病的人数均 高于非MS 组（P <0.05）；合并MS 组膝关节疼痛（VAS）评分、膝关节功能（WOMAC）评分、Kellgren- Lawtence（K-L）分级评分均高于非MS 组（P <0.05）。合并MS 组空腹血糖（GLU）、胆固醇（TG）、血清 总胆固醇（TCH）、低密度脂蛋白胆固醇（LDL-C）及红细胞沉降率（ESR）均较非MS 组升高（P <0.05）。 结论 膝骨关节炎合并代谢综合征的患者危险因素多，代谢紊乱程度严重及关节病情严重，应给予有效的干预 措施。

Abstract:

Objective To explore the clinical characteristics of knee osteoarthritis (KOA) complicated with metabolic syndrome (MS). Methods A total of 390 patients with KOA in Xuanwu hospital, Capital Medical University from January 2015 to September 2017 were enrolled in this survey. The subjects were divided into MS group (151 cases) in which patients had MS and non-MS group (239 cases) in which patients did not have MS. Clinical data were recorded. Results Gender ratio between two groups was statistically significant (P < 0.05). BMI, waist circumference, diastolic blood pressure and systolic blood pressure in MS group were higher than those in non- MS group (P < 0.05). The prevalence of hypertension, diabetes, coronary heart disease and cerebrovascular disease in MS group were increased compared with non-MS group (P < 0.05). The VAS score, WOMAC score and K-L grading score were enhanced in MS group than those in the non-MS group (P < 0.05). The levels of GLU, TG, TCH, LDL-C and ESR of the MS group were significantly upregulated when compared with those in non-MS group (P < 0.05). Conclusion Patients with KOA combined with MS experience severe metabolic disorder and joint disease, who should receive effecfive inferventions.