Hepcidin 蛋白与乳腺癌骨转移的关系

Role of Hepcidin in bone metastasis of breast cancer

摘要:

目的 分析乳腺癌及乳腺癌骨转移患者的Hepcidin 蛋白及相关指标，探讨Hepcidin 在乳腺癌发生、 发展中的作用。方法 回顾性分析江苏省常州市第一人民医院乳腺癌骨转移患者25 例、乳腺癌无骨转移患者30 例及乳腺增生患者30 例。比较3 组患者Hb、Hepcidin、BMP-6、IL-6、sTfR 的差异。用ROC 曲线分析评价 Hepcidin、BMP-6、IL-6 对乳腺癌骨转移的诊断价值。多因素Logistic 回归分析比较各指标在乳腺癌骨转移的作用。 结果 3 组患者Hb、Hepcidin、BMP-6、IL-6、sTfR 差异有统计学意义（P <0.05）。对Hepcidin 及BMP-6， 乳腺癌骨转移组> 乳腺癌无骨转移组> 乳腺增生组；对IL-6，乳腺癌骨转移组> 乳腺癌无骨转移组及乳腺增 生组，但后两组比较差异无统计学意义（P >0.05）；对Hb，乳腺癌骨转移组< 乳腺癌无骨转移组< 乳腺增生组； 对于sTfR，乳腺癌骨转移组< 乳腺癌无骨转移组< 乳腺增生组。ROC 曲线分析发现Hepcidin 对于乳腺癌骨转 移均有较高诊断价值，且优于BMP-6、IL-6。多因素分析发现Hepcidin 是乳腺癌骨转移的独立危险因素。结论 Hepcidin 与乳腺癌骨转移有较好的相关性，其诊断价值有待进一步研究。

Abstract:

Objective To investigate role of Hepcidin in bone metastases of breast cancer and its clinical significance. Methods A retrospective analysis of 25 breast cancer patients with bone metastases, 30 breast cancer patients without bone metastases, and 30 patients with breast hyperplasia was conducted. Levels of Hb, Hepcidin, BMP-6, IL-6, and sTfR were measured. Statistical analysis was performed to evaluate the diagnostic value of Hepcidin, BMP-6 and IL-6 in bone metastasis in breast cancer. Results Patients with bone metastasis experienced highest levels of Hepcidin, BMP-6 and IL-6, followed by patients without bone metastasis and patients with breast hyperplasia (P < 0.05). Patients with breast hyperplasia experienced highest levels of Hb and sTfR, followed by patients without bone metastasis and patients with breast hyperplasia (P < 0.05). ROC analysis showed that Hepcidin was superior to BMP-6 and IL-6 as a diagnostic marker for breast cancer with bone metastasis. Multivariate analysis showed that Hepcidin was an independent risk factor for breast cancer with bone metastasis. Conclusion Hepcidin may be a promising diagnostic biomarker for bone metastasis of breast cancer.