局部晚期宫颈癌预后因素的研究进展

Brief review on prognostic factors of locally advanced cervical cancer

摘要:

宫颈癌是常见的妇科恶性肿瘤，严重危害女性健康，手术、放化疗等综合治疗是目前主要的治疗 手段。>30% 宫颈癌患者就诊时即为局部晚期（FIGO II B ～ IVA 期），该期患者治疗以同步放化疗为主，虽然 近期疗效较理想，但是长期随访数据显示易出现复发和转移，远期预后差。目前主要依据临床FIGO 分期对 宫颈癌患者进行治疗指导及预后判断，然而患者自身状况、肿瘤大小、淋巴结转移情况、病理及治疗手段等 其他因素均会影响宫颈癌患者预后。全面评估患者，筛选出可能影响患者预后的高危因素，及时调整治疗方 式并判断预后具有重要意义。本文从患者基本情况、流行病学因素、肿瘤病理因素及治疗状况等多个方面对 局部晚期宫颈癌患者预后因素的临床研究进展进行概述。

Abstract:

Cervical cancer is a common malignant gynecological tumor and still poses a threat to women's health. Comprehensive treatment such as surgery, radiotherapy and chemotherapy is currently the main treatment model. More than 30% patients with cervical cancer are locally advanced (FIGO stage IIB-IVA), and treatment for the patients in this phase is mainly concurrent radiochemotherapy. Although, short-term effect for locally advanced cervical cancer is comparatively ideal, the long-term follow-up shows tendency of relapse and poor survival. The current FIGO staging can initially provide us with the guidance of treatment and judgement for prognosis, but other factors such as the patient's own condition, tumor size, lymphadenopathy status and treatment methods have influences on the prognosis too. Comprehensive assessments of prognosis and screening out high-risk factors are of great significance. This article discusses the clinical research progress on the prognostic factors of locally advanced cervical cancer.