透明质酸对膝关节骨性关节炎相关细胞因子 及生物标志物的影响

Research progress of osteoarthritis-related cytokines and biomarkers in the treatment of knee osteoarthritis with hyaluronic acid

摘要:

骨性关节炎（OA）是一种由不同病因引起的综合征最终聚集在同一致病途径上，产生软骨、 软骨下骨和滑膜的特征性变化。OA 由于软骨破坏及其代谢改变，可在其体液中寻找反映软骨结构变化的相 关细胞因子和特异性生物标志物，这对于OA 的诊疗及预后评估起到积极的指导作用。关节腔注射透明质酸 （HA）是治疗膝关节OA 最常用的有效方法，其可刺激内生HA 分泌，润滑关节组织，也可有效防止软骨降解。 此外，关节腔注射HA 可以降低金属蛋白酶含量，减少促炎介质的产生，从而减少参与OA 发病机制的因素， 改善关节炎症症状和关节软骨的损伤。

Abstract:

Osteoarthritis (OA) is a syndrome caused by different causes, which finally converge on the same pathogenic pathway producing characteristic changes in cartilage, subchondral bone, and synovial membrane. As a result of cartilage breakdown and its metabolic changes, osteoarthritis-related cytokines and specific biomarkers reflecting changes in cartilage structure can be found in their body fluids, which will play a positive role in the diagnosis, treatment and prognosis evaluation of osteoarthritis. Intra-articular injection of hyaluronic acid (HA) is the most common and effective method for the treatment of knee osteoarthritis. It can stimulate endogenous hyaluronic acid secretion to lubricate joint tissue and prevent cartilage degradation. In addition, intra-articular injection of hyaluronic acid can reduce the content of metalloproteinases and the production of pro-inflammatory mediators, thereby reducing the factors involved in the pathogenesis of osteoarthritis and improving the symptoms of arthritis and the damage of articular cartilage.