血浆T-tau、Aβ-42 与维持性血液透析患者 轻度认知功能障碍的相关性研究

Relationship between plasma T-tau, Aβ-42 protein content and mild cognitive impairment in dialysis patients

摘要:

目的 探讨血浆T-tau、Aβ-42 蛋白浓度与维持性血液透析患者认知功能障碍的相关性。方法 采用酶联免疫吸附法检测轻度认知功能障碍（MCI）组、认知功能正常组（对照组）血浆T-tau、Aβ-42 蛋白浓度。 分析两组血浆T-tau、Aβ-42 蛋白浓度差异，及其与其他临床指标的相关性。结果 MCI 组较对照组血浆 T-tau 蛋白浓度升高（P <0.05）；两组Aβ-42 蛋白浓度比较，差异无统计学意义（P >0.05）；两组血浆T-tau 蛋白浓度与尿素下降率、每2 周透析时间呈负相关（r =-0.249，P =0.020）；T-tau ≥ 980.96 pg/ml 为MCI 的危 险因素[O^R=1.521（95%CI ：1.168，1.981），P =0.002]。结论 维持性血液透析MCI 患者血浆T-tau 蛋白浓度较 认知功能正常者升高，降低血浆T-tau 蛋白浓度可能是预防维持性血液透析患者MCI 的有效手段。

Abstract:

Objective To explore the relationship between plasma T-tau, Aβ-42 protein and mild cognitive impairment (MCI) in dialysis patients. Methods ELISA was used to detect T-tau and Aβ-42 protein concentrations in plasma between MCI group and cognitive normal group (control group). Results The concentration of T-tau in MCI group was higher than that in control group (P < 0.05); The difference of Aβ-42 concentrations in two groups had no statistical significance (P > 0.05). The concentration of plasma T-tau was negative correlation with urea nitrogen clearance rate and the dialysis time every two weeks (r = -0.249, P = 0.020). T-tau ≥ 980.96 pg/ml was the independent risk factor [Ol ^ R = 1.521, (95% CI: 1.168, 1.981), P = 0.002]. Conclusions The concentration of plasma T-tau in dialysis patients with MCI is higher than that in patients with normal cognitive function. Reducing the concentration of plasma T-tau may be an effective mean to prevent cognitive dysfunction in dialysis patients.