合肥地区甲状腺功能异常患者 治疗前后碘营养状态比较

Comparison of iodine nutritional status of patients with thyroid dysfunction in Hefei area before and after treatment

摘要:

目的 观察合肥地区不同甲状腺功能状态人群甲状腺功能转归和碘营养状况的关系，为探讨合 肥地区合适的食盐加碘剂量提供理论依据。方法 选取合肥市114 例成人甲状腺功能亢进（以下简称甲亢） 和176 例甲状腺功能减退（以下简称甲减）患者，同时选取合肥市区社区人群性别、年龄匹配的300 例正常 人作为对照组。检测甲状腺功能、甲状腺相关抗体及尿碘浓度。根据患者甲状腺疾病病因及功能状况予以 抗甲药物或左甲状腺素口服治疗，保持甲状腺功能正常6 个月后复查尿碘浓度。结果 ①甲亢组尿碘浓度最 高[（376.43±146.39）μg/L]，甲减组为[（349.15±132.74）μg/L]，两组为碘过量状态，对照组尿碘浓度为 [（268.60±103.90）μg/L]，为碘超足量状态。3 组尿碘浓度比较，差异有统计学意义（P <0.05）。②甲亢、甲 减组治疗后尿碘浓度较治疗前降低（P <0.05）。结论 合肥地区普通人群为碘超足量，甲亢和甲减患者存在 碘过量，经治疗维持甲状腺功能正常后碘营养状况改善。

Abstract:

Objective To observe the status of iodine nutrition in different thyroid functional states in Hefei, and to observe the relationship between thyroid function and iodine nutrition, and to provide a theoretical basis for the study of suitable iodized salt dosage in Hefei area. Methods Totally 114 cases of adult hyperthyroidism in Hefei City and 176 cases of hypothyroidism were selected, and 300 cases of normal people with gender and age matched in the community of Hefei were compared as control group. The thyroid function, thyroid related antibody and urinary iodine concentration were detected. According to the etiology and function of thyroid disease, the patients were treated with antithyroid drugs or levothyroxine, and the concentration of urinary iodine was reexamed after 6 months. Results ① The concentration of urinary iodine was highest in patients with hyperthyroidism (376.425 ± 146.394μg/L), and that with hypothyroidism was (349.154 ± 132.735μg/L). Both groups were excessive iodine status. The concentration of urinary iodine in the control group was (268.597 ± 103.902μg/L), which was more than adequate. There were statistically significant differences in urine iodine concentrations in three groups (P < 0.05). ② The concentration of urine iodine after treatment significantly decreased in both hyperthyroidism group and hypothyroidism group (P < 0.05). Conclusions The general population in Hefei area is more than adequate of iodine, the hyperthyroidism and hypothyroidism in Hefei area are excessive iodine status, and the iodine nutritional status is improved after maintenance of normal thyroid function.