膝关节骨性关节炎软骨损伤的MRI 形态评分 及T2 值变化与临床表现的相关性

MRI morphological scores of cartilage injury in knee joint osteoarthritis and correlation between changes of T2 value and clinical features

摘要:

目的 探讨膝关节骨性关节炎（OA）软骨损伤MRI 形态评分及T2 值变化与临床表现的相关性。 方法 选取2016 年9 月—2017 年7 月在武汉市第一医院诊治的膝关节OA 患者72 例作为研究组，选取同期 该院健康体检者20 例作为对照组，所有研究对象进行MRI 检查。比较两组膝关节软骨不同区域T2 值，采用 骨关节炎指数（WOMAC）和全器官磁共振评分（WORMS）分别评估两组研究者症状程度和MRI 检查严 重程度，分析T2 值与WOAMC、WORMS 的相关性。结果 研究组股骨外侧区（LF）、股骨内侧区（MF）、 胫骨外侧区（LT）、胫骨内侧区（MT）及髌骨区（P）区域软骨T2 值高于对照组（P <0.05）；Pearson 相关 分析结果表明，膝关节OA 患者LF 区域T2 值与WORMS 评分无相关性（P >0.05）；膝关节OA 患者MF、 LT、MT 及P 区域T2 值与WORMS 评分均呈正相关（P <0.05）；膝关节OA 患者僵硬、疼痛、关节功能 WOMAC 评分及WOMAC 总分与T2 值呈正相关（P <0.05）。结论 MRI 检查T2 值与膝关节OA 患者临床症状、 软骨病变程度呈正相关，MRI 检查能反映膝关节OA 患者软骨损伤程度。

Abstract:

Objective To investigate the relationship between MRI morphological scores, changes of MRI T2 value and clinical manifestations of cartilage injury in knee osteoarthritis (OA). Methods To select 72 cases of knee OA patients in our hospital from Sept. 2016 to Jul. 2017 as a research group and 20 volunteers in our hospital physical examination center health during the same period as a control group, and all subjects were examined by MRI. The T2 values of different regions of knee cartilage were compared between the two groups. The degree of symptoms and the severity showed by MRI were respectively evaluated by WOMAC and WORMS. The correlations between T2 value and WOAMC, WORMS were analyzed. Results The cartilage T2 values of LF, MF, LT, MT and P in the research group were significantly higher than those in the control group (P < 0.05). Pearson analysis showed that there was no correlation between T2 value of LF and WORMS score in knee OA patients (r = 0.011, P > 0.05). There was a positive correlation between T2 value of MF, LT, MT, P and WORMS score (r = 0.814, 0.856, 0.721, 0.615, all P < 0.05). Pearson analysis showed that stiffness, pain, WOMAC scores of joint function and total WOMAC score were positively correlated with T2 values (r = 0.316, 0.294, 0.409 and 0.325, all P < 0.05). Conclusions MRI T2 values and clinical symptoms of knee OA patients, degree of cartilage lesion were positively correlated. MRI can reflect the degree of cartilage injury in knee OA patients.