UCH37 与非小细胞肺癌患者预后的相关性研究

Prognostic significance of ubiquitin carboxyl-terminal hydrolase 37 in patients with non-small cell lung cancer

摘要:

目的??检测泛素化羧基末端水解酶 37（UCH37）在非小细胞细胞肺癌组织中的表达情况，研究 UCH37 的表达与非小细胞肺癌患者的临床病理特征及生存预后之间的关系。方法??通过实时荧光定量聚合 酶链反应（qRT-PCR）检测非小细胞肺癌患者组织及对照癌旁组织中 UCH37 的表达情况，分析 UCH37 的 临床意义。结果??与癌旁组织比较，UCH37 在非小细胞肺癌组织中的表达增高（ P <0.05） ； UCH37 在非小细 胞肺癌组织中的表达与患者肿瘤的 TNM 分期、淋巴结转移相关（ P <0.05） ，生存曲线显示非小细胞肺癌组织 中 UCH37 高表达的患者术后总体生存率、无进展生存率低于低表达者（ P <0.05） ； Cox 比例风险回归模型 证实 UCH37 可作为非小细胞肺癌判断预后的预测指标 [H ^ R=2.221（95%?CI ： 1.367，3.437） ， P =0.038]。结论? UCH37 表达在非小细胞肺癌组织中升高， 并可作为判断非小细胞肺癌患者生存及预后的评价指标。

Abstract:

Objective To investigate the expression and prognostic value of ubiquitin carboxyl-terminal hydrolase 37 (UCH37) in non-small cell lung cancer. Methods QRT-PCR was performed to detect the expressions of UCH37 in non-small cell lung cancer patients tissues. The clinical relevance of UCH37 in non-small cell lung cancer was analyzed by Chi-square analysis and Cox proportional hazards risk analysis. Results qRT-PCR suggested that levels of UCH37 were significantly higher in non-small cell lung cancer tissues compared with adjacent tissue (P < 0.05). High expression of UCH37 was significantly associated with TNM stage and lymph node status of non- small cell lung cancer (P < 0.05). Patients with increased expression of UCH37 experienced lowered 5 years overall survival rate (P = 0.009) and progression-free survival (P = 0.032) after surgery. Cox proportional hazards regression model confirmed that UCH37 can be used as a predictor of prognosis in non-small cell lung cancer [H ^ R = 2.221, (95% CI: 1.367, 3.437), P = 0.038). Conclusions Upregulated UCH37 may be a valuable prognostic biomarker for non-small cell lung cancer.