IgA 肾病患者高血压发生特点及相关危险因素分析

Clinical characteristics of hypertension in patients with IgA nephropathy

摘要:

目的??探讨 IgA 肾病（IgAN）患者高血压的发生特点及其相关危险因素。方法??对纳入的新疆维 吾尔自治区人民医院 675 例 IgAN 患者的一般资料、临床和病理资料进行回顾性研究，分析患者发生高血压 的特点，并且运用单因素和多因素方法分析高血压发生的危险因素。结果??675 例 IgAN 患者，高血压发生率 为 40.80%。不同民族和年龄组间高血压的发生率存在差异； IgAN 患者 CKD 分期和牛津分级 MEST 评分越高， 高血压发生率越高 ； Logistic 回归结果表明年龄、高血压家族史、血肌酐水平、24?h 尿蛋白定量、体重指数及 肾血管病变程度等是 IgAN 患者高血压发生的主要危险因素。结论??IgAN 呈进行性发展，高血压是其常见的 临床症状， 发生的特点及相关危险因素多种多样， 因此对 IgAN 患者进行早期干预治疗尤为重要。

Abstract:

Objective To investigate the characteristics of hypertension and related risk factors in patients with IgA nephropathy. Methods The general data, clinical and pathological data of 675 IgA nephropathy patients were involved and retrospectively analyzed in this study. Risk factors of hypertension in IgA nephropathy patients were screened by single factor and multivariate methods. Results Incidence of hypertension in 675 patients with IgA nephropathy was 40.80%. Occurrence of hypertension were affected by nationalities, age, stage of chronic kidney disease and Oxford classification MEST score. Logistic regression analysis showed that age, family history of hypertension, serum creatinine, 24-hour urine protein, body mass index and renal vascular disease were the main risk factors for hypertension in IgA nephropathy patients. Conclusions Hypertension is a common complication of IgA nephropathy with various characteristics and risk factors.