云克和玻璃酸钠治疗膝骨关节炎合并滑膜炎的疗效观察

Therapeutic effect of Sodium hyaluronate and Yunke on knee osteoarthritis complicated with synovitis

摘要:

目的??探讨与观察云克和玻璃酸钠治疗膝骨关节炎（KOA）合并滑膜炎的疗效。方法??选取 2014 年 6 月—2017 年 2 月海南医学院第一附属医院诊治的 KOA 合并滑膜炎患者 60 例。根据随机数字表法分为观察组 和对照组，每组 30 例，对照组给予玻璃酸钠治疗，观察组在对照组治疗的基础给予云克治疗，都治疗观察两疗 程。结果??观察组与对照组总有效率为 96.7% 和 76.7%，两组比较差异有统计学意义（ P <0.05） 。两组治疗后的 VAS 评分降低， Lysholm 评分升高， 与治疗前比较差异有统计学意义（ P <0.05） ， 治疗后观察组与对照组比较差异 有统计学意义（ P <0.05） 。治疗后观察组与对照组的 CRP 分别为（4.76±3.42）和（11.14±3.19）mg/L，均低于 治疗前的（27.44±8.24）和（26.98±7.13）mg/L，差异有统计学意义（ P <0.05） ，观察组与对照组比较差异有统 计学意义（ P <0.05） 。观察组与对照组治疗后的外周血 CD3 + 值和 CD3 + CD8 + 值均高于治疗前，差异有统计学意 义（ P <0.05） ，观察组与对照组比较差异有统计学意义（ P <0.05） 。结论??云克和玻璃酸钠治疗 KOA 合并滑膜炎能促进机体免疫功能的恢复， 快速缓解和改善膝关节疼痛， 促进 CRP 降低， 从而提高治疗疗效。

Abstract:

Objective To investigate and observe the effect of Sodium hyaluronate and Yunke on knee osteoarthritis (KOA) complicated with synovitis. Methods Sixty patients with KOA combined with synovitis were enrolled in The First Affiliated Hospital of Hainan Medical University from June 2014 to February 2017. According to the random number table method, the patients were divided into the observation group and the control group, 30 cases in each group. The control group was given Sodium hyaluronate treatment, and the observation group was given Yunke treatment on the basis of the control group. Both treatments were observed for two courses. Results The total effective rates in the observation group and the control group were 96.7% and 76.7%, respectively, and the total effective rate in the observation group was higher than that of the control group (P < 0.05). The VAS scores of the two groups were obviously decreased, and the scores of Lysholm were significantly increased after treatment (P < 0.05). After treatment, the scores of VAS and Lysholm in the observation group were significantly different from those in the control group (P < 0.05). After treatment, the CRP of the observation group and the control group were (4.76 ± 3.42 mg/L) and (11.14 ± 3.19 mg/L) respectively, which were lower than (27.44 ± 8.24 mg/L) and (26.98 ± 7.13 mg/L) before treatment (P < 0.05), and the CRP in the observation group was lower than that in the control group (P < 0.05). CD3 + and CD3 + CD8 + values of peripheral blood in the observation group and the control group after treatment were significantly higher than those before treatment (P < 0.05), and CD3 + and CD3 + CD8 + values in the peripheral blood of the observation group after treatment were significantly higher than those of the control group (P < 0.05). Conclusions The treatment of KOA with synovitis by Yunke and Sodium Hyaluronate can promote the recovery of immune function, rapidly relieve and improve knee pain, and promote the reduction of CRP, thus improving the therapeutic effect.