HSPA9、Beclin-1 在甲状腺滤泡癌中的 表达及其相关性分析

Expression and correlation of HSPA9 and Beclin-1 in follicular thyroid carcinoma

摘要:

目的 探讨甲状腺滤泡癌（FTC）中热休克蛋白A9（HSPA9）、Beclin-1 的表达及其与肿瘤发生、 发展的关系。方法 选取57 例FTC 组织及其相应的癌旁组织，用免疫组织化学法检测HSPA9、Beclin-1 蛋 白的表达，分析HSPA9、Beclin-1 表达与FTC 患者临床病理特征的关系及其两者表达的相关性。结果 FTC 组织中HSPA9、Beclin-1 的表达高于癌旁组织（P <0.05）；不同病理类型、是否远处转移患者HSPA9 阳性 率比较，差异有统计学意义（P <0.05）；不同病理类型患者Beclin-1 阳性率比较，差异有统计学意义（P <0.05）。 FTC 组织中HSPA9 与Beclin-1 呈正相关（P <0.05）。结论 HSPA9、Beclin-1 蛋白可能与FTC 的发生、发 展密切相关。

Abstract:

Objective To investigate the expression of HSPA9 and Beclin-1 in follicular thyroid carcinoma (FTC) and their roles in the occurrence and development of thyroid tumors. Methods Totally 57 cases of FTC tissue and corresponding adjacent tissues were selected, and the expression of HSPA9 and Beclin-1 protein were detected by immunohistochemistry method. The relationship between the expression of HSPA9, Beclin-1 and the clinicopathological features of the patients with FTC and the correlation between HSPA9 and Beclin-1 were analyzed. Results The expressions of HSPA9 and Beclin-1 in FTC were higher than those in normal tissues adjacent to cancer (P < 0.05); the positive rate of HSPA9 in patients with different pathological types and distant metastasis was significantly different (P < 0.05); the positive rate of Beclin-1 in patients with different pathological types was significantly different (P < 0.05). There was a positive correlation between the expression of HSPA9 and Beclin-1 in FTC (P < 0.05). Conclusions HSPA9 and Beclin-1protein may be closely related to the occurrence and development of FTC.