蛋白质组学的研究现状及其在2 型糖尿病中的应用

Application and progress of proteomics in type 2 diabetes

摘要:

蛋白质组学是对基因编码蛋白质进行大规模分析的一门新兴学科。本文概述蛋白质组学的基本 技术：双相凝胶电泳、多维液相色谱、生物质谱技术及蛋白质芯片在2 型糖尿病（T2DM）中的应用，从而 探讨T2DM 中与炎症及脂代谢紊乱相关的生物蛋白：C 反应蛋白、α2- 巨球蛋白、载脂蛋白A1、Clusterin 及锌-α-2 糖蛋白的研究进展，发现早期诊断T2DM 新的特异性标志物及药物作用靶点。

Abstract:

Proteomics is a new subject for large-scale analysis of gene coding protein. This paper describes the basic technology of proteomics: application two-dimensional gel electrophoresis, multidimensional liquid chromatography, mass spectrometry, protein chip and their application in type 2 diabetes, to explore the biological protein related to inflammation and dyslipidemia in type 2 diabetes, such as C reaction protein, alpha macroglobulin, apolipoprotein 2-A1, Clusterin protein and zinc alpha-2 glycoprotein, and to find some new mellitus specific markers and drug targets for early diagnosis of type 2 diabetes.