百令胶囊辅助治疗对稳定期COPD 患者 气道功能及血清气道重塑分子的影响

Effect of Corbrin capsule on airway function and serum airway remodeling molecules in patients with stable COPD

摘要:

目的 探讨百令胶囊辅助治疗对稳定期慢性阻塞性肺疾病（COPD）患者气道功能及血清气道 重塑分子的影响。方法 选取2016 年1 月—2017 年12 月于德阳市人民医院接受治疗的稳定期COPD 患者 80 例作为研究对象，按照随机数表法将其分为对照组和百令胶囊组。对照组患者接受临床稳定期COPD 常 规治疗，百令胶囊组患者在常规治疗基础上加入百令胶囊辅助治疗，持续8 周。对比治疗前、治疗8 周后两 组患者气道功能参数水平及血清气道重塑分子含量的差异。结果 百令胶囊组治疗8 周后第1 秒用力呼气容 积、第1 秒用力呼气容积占用力肺活量的比值、剩50% 肺活量时的最大呼气流速、中段呼气流速及剩25% 肺活量时的用力呼气流速高于对照组（P <0.05）。百令胶囊组治疗8 周后转化生长因子-β1、烟酰胺腺嘌呤 二核苷酸磷酸氧化酶4、核因子-κB 及基质金属蛋白酶-9 低于对照组（P <0.05）。结论 稳定期COPD 患 者在常规治疗基础上加入百令胶囊辅助治疗，可有效优化气道功能并抑制气道重塑分子的表达。

Abstract:

Objective To study the effect of Corbrin capsule on airway function and serum airway remodeling molecules in patients with stable COPD. Methods During January 2016 to December 2017, 80 cases of stable COPD patients undergoing treatment in our hospital were selected as research subjects, and were divided into control group (n = 40) and Corbrin capsule group (n = 40). Patients in control group were treated with routine COPD treatment for 8 weeks, and those in Corbrin capsule group were treated with Corbrin capsule for 8 weeks on the basis of routine treatment. The difference of airway function parameters and serum contents of airway remodeling molecule between two groups before and 8 weeks after treatment were compared. Results Levels of airway function parameters such as FEV1, FEV1/FVC, MEF50, MEF25-75 and MEF25 in Corbrin capsule group were higher than those in control group (P < 0.05); serum contents of TGF-β1, NOX4, NF-κB and MMP-9 in Corbrin capsule group were lower than those in control group (P < 0.05). Conclusions Adding Corbrin capsules to stable COPD patients on the basis of routine treatment can effectively optimize airway function and inhibit the expression of airway remodeling molecule.