精神分裂症认知测评及矫正对症状转归的影响

Effect of cognitive assessment and correction on symptom outcome of schizophrenia

摘要:

目的 探讨精神分裂症患者认知功能测评及认知矫正对症状转归的影响。方法 选取2015 年 6 月—2017 年6 月于武汉市精神卫生中心就诊的96 例精神分裂症患者作为研究对象，采用抽签法分为研究组 和对照组。两组患者均给予常规药物治疗、参与工娱活动。研究组在常规治疗的基础上给予计算机认知功能 矫正治疗，两组患者均治疗12 周。患者治疗前后采用阳性与阴性症状量表（PANSS）评估病情严重程度，威 斯康星卡片分类测验（WCST）、韦氏成人智力量表（WAIS-RC）、连线测试（TMT）测评认知功能，自尊 量表（SES）、个人社会功能量表（PSP）及社会功能缺陷筛选量表（SDSS）测评患者的自尊水平和社会功能。 结果 研究组治疗后PANSS 各维度评分均低于对照组（P <0.05）；研究组治疗后完成卡片总数、正确分类数 及数字广度得分高于对照组（P <0.05），随机错误数、持续错误数及连线时间低于对照组（P <0.05）；研究组 治疗后SES 和PSP 得分高于对照组（P <0.05），而SDSS 得分低于对照组（P <0.05）。结论 认知功能矫正治 疗精神分裂症患者疗效良好，认知功能改善与患者病情及临床症状的转归相关。

Abstract:

Objective To investigate the cognitive function assessment and cognitive correction on symptom outcome of patients with schizophrenia. Methods A total of 96 patients with schizophrenia who were admitted to our hospital from June 2015 to June 2017 were enrolled in the study. Each 48 patients in the study group and the control group were given the same medicine treatment and Participated in recreational activities. The research team were given computer cognitive function correction treatment on the basis of conventional treatment, and both groups were treated for 12 weeks. Before and after treatment, the positive and negative symptom scale (PANSS) was used to assess the severity of the disease, and the Wisconsin card classification test (WCST), the Wechsler adult intelligence scale (WAIS-RC) and the Wireline test (TMT) were used to measure cognitive function, and the amount of selfesteem table (SES), personal social function scale (PSP) and social function deficit screening scale (SDSS) were used to measure patient self-esteem levels and social function. Results After treatment, the scores of PANSS in the study group were lower than those in the control group (P < 0.01); the total number of completed cards, correct classification and digital breadth scores of WCST were higher than those in the control group (P < 0.05), the number of random errors and continuous errors and connection time were less than those in the control group (P < 0.05); the SES score and PSP score were higher than those in the control group (P < 0.05), while the SDSS score was lower than those in the control group (P < 0.05). Conclusions Cognitive function correction is effective in the treatment of patients with schizophrenia, and the cognitive function improvement is associated with the outcome of the patient’s condition and clinical symptoms.