静息心率对代谢综合征的影响

Effect of resting heart rate on metabolic syndrome in healthy population

摘要:

目的 探讨静息心率（RHR）对不同性别健康人群进展为代谢综合征（MS）的影响。方法 选 取2011 年1 月—2012 年12 月聊城市第二人民医院的健康体检者作为研究对象，并进行5 年的随访。采用 Logistic 回归分析不同RHR 水平与MS 发病率的关系。结果 随访5 年后，男性组和女性组MS 发病率随着 RHR 的增快而升高（P <0.05）。对于总人群，随着RHR 每增加1 个单位，MS 的发病风险显著增加，经过年龄、 BMI、健康相关行为及预先存在的MS 组分校正后差异仍有统计学意义[Ol ^ R=1.320，（95% CI ：1.201，1.451）， P =0.000] ；经性别分层后差异仍有统计学意义[ 男性组：Ol ^ R=1.192，（95% CI ：1.040，1.367），P =0.012 ；女 性组：Ol ^ R=1.409，（95% CI ：1.235，1.608），P =0.000]。对于总人群，以RHR ＜ 70/min 为参照组，其余3 组 的MS 发病风险均显著增加，且OR 呈递增趋势；经过年龄、BMI、健康相关行为及预先存在的MS 组分校 正后差异仍有统计学意义[RHR ≥ 90/min 组：Ol ^ R=2.327，（95% CI ：1.784，3.037），P =0.000]。经性别分层 后差异仍有统计学意义[RHR ≥ 90/min 组中男性组：Ol ^ R=1.644，（95% CI：1.148，2.355），P =0.007]；女性组： Ol ^ R=3.375，（95% CI ：2.214，5.146），P =0.000]。结论 RHR 与MS 有着密切的关联性，随着RHR 的加快， MS 风险逐渐升高，这种影响是独立的，且在女性人群中更为显著。

Abstract:

Objective To study the effects of resting heart rate (RHR) on metabolic syndrome (MS) in healthy population. Methods The health examinees of our hospital from January 2011 to December 2012 were selected as the research subjects and followed up for 5 years. Logistic regression was used to analyze the relationship between different RHR levels and the incidence of MS. Results After 5-year follow-up, the incidence of MS in both male and female groups increased with the increase of RHR (χ2 male=10.039, P = 0.002; χ2 female=48.437, P = 0.000). For the total population, the risk of MS increased significantly with the increase of RHR by 1 unit, and the difference was still statistically significant after adjusting for age, BMI, health-related behavior and pre-existing MS components [Ol ^ R=1.320 (95% CI=1.201, 1.451); P = 0.000]. There was still significant difference after sex stratification [male group: Ol ^ R=1.192 (95% CI=1.040, 1.367), P = 0.012; female group: Ol ^ R=1.409 (95% CI=1.235, 1.608), P < 0.001]. For the total population, RHR<70/min as the control group, the risk of MS in the remaining three groups were significantly increased, and OR showed an increasing trend; after correction of age, BMI, health-related behavior and pre-existing MS component, there was still significant significance [RHR<90/min group: Ol ^ R=2.327 (95% CI=1.784, 3.037), P = 0.000]. There was still significant difference after sex stratification [[RHR>90/min group: male group: Ol ^ R=1.644 (95% CI=1.148, 2.355), P = 0.007; female group: Ol ^ R=3.375 (95% CI=2.214, 5.146), P < 0.05]. Conclusions In conclusion, an increase in resting heart rate was an independent and signi?cant predictor of MS in all people, especially in women.