血清Periostin水平在儿童支气管哮喘控制管理中的临床意义*

Clinical significance of serum Periostin in children bronchial asthma*

摘要:

目的 探讨Periostin在支气管哮喘发病过程中的作用，以及在哮喘控制管理中的临床意义。方法 选取白求恩国际和平医院支气管哮喘患儿148例为哮喘组，按其控制水平分为哮喘未控制组58例、部分控制组45例、良好控制组45例。同期选取健康体检儿童27例作为对照组。应用酶联免疫吸附试验（ELISA）检测其血清Periostin水平，哮喘患儿行肺功能检查。结果 ①支气管哮喘未控制组血清Periostin水平高于对照组、部分控制组及良好控制组（P?<0.05）；②支气管哮喘良好控制组血清Periostin水平低于对照组（P?<0.05）；③支气管哮喘部分控制组血清Periostin水平与对照组和良好控制组比较，差异无统计学意义（P?>0.05）；④支气管哮喘未控制组、部分控制组、良好控制组肺功能FEV1 %处于递增趋势（P?<0.05）；⑤哮喘组患儿血清Periostin水平与FEV1 %呈负相关（r?=-0.729，P?=0.000）。结论 未控制的哮喘患儿血清Periostin水平升高，但其水平不能判断疾病控制情况。

Abstract:

Objective To investigate the clinical significance of serum Periostin in children asthmatic. Methods A total of 148 cases of children asthma were involved in this study. Children were sub-grouped into uncontrolled asthma (n?=?58), partly controlled asthma (n?=?45), complete controlled asthma (n?=?45) and healthy controls (n?=?27). Enzyme-linked immunosorbent assay (ELISA) was performed to detect the serum Periostin. Lung function was examined in all asthmatic children. Results The serum level of Periostin was the highest in uncontrolled asthmatic while that was the lowest in complete controlled group (P?< 0.05). No statistically significant difference in serum Periostin was observed between partly controlled group and healthy controls (P?>?0.05). Children in complete controlled group experienced the highest value of FEV1 % in complete controlled group when compared with that in other asthmatic children (P?