Objective To explore the use of physical therapy combined with traditional rehabilitation methods to treat chronic hemophilia pain. Methods Nine patients with hemophilic chronic pain were treated with physical therapy and therapeutic massage for 3 weeks, using visual analogue (VAS) score, hemophilia joint health score scale (HJHS) score and functional independence score in hemophilia (FISH) were assessed before and after the treatment. Results There was a significant difference on VAS and FISH score before and after the treatment, while no statistical change was found on HJHS. Conclusions Comprehensive rehabilitation therapy can not only relieve the pain, but also improve the patients’ activities of daily life (ADL) with chronic pain of hemophilia.