Abstract:Objective To explore the mediating effect of self-esteem on social support for male drug addicts with different personality. Methods Totally 225 male drug addicts were surveyed by using Self-esteem Scale, Social Support Questionnaire and Eysenck Personality Questionnaire. All data were analyzed by Stata12.0. Results 1. In terms of the objective support, subjective support and social support utilization, the scores of the juvenile group were lower than that of the adult group, and the difference was statistically significant (P < 0.05); 2. The score of juvenile group in P (Psychot icism) dimension was lower than that of the adult group, and the difference was statistically significant (P < 0.05); 3. From personality type to self-esteem, E (Extraversion/Introversion) dimension and N (Neuroticism) dimension had significant influence. The indirect effects of the relationship were statistically significant (P < 0.05). Conclusion Self-esteem (SES) as a mediator significantly affects the relationship between personality and social support, and its indirect effects were significant on the E (Extraversion/Introversion) dimension and N (Neuroticism) dimension. The low level of self-esteem and the lack of social support have become the main obstacles to return society for drug addicts. There should be training for boosting self-confidence and self-esteem for drug addicts. Their subjective feelings of social support should be cultivated, and family and social acceptance of them should be enhanced.