慢性阻塞性肺疾病患者血清CTRP-9 水平 及其临床意义

Serum level of C1q tumor necrosis factor related protein 9 in patients with chronic obstructive pulmonary disease and its clinical significance

摘要:

目的 探讨慢性阻塞性肺疾病（COPD）患者血清C1q 肿瘤坏死因子相关蛋白9（CTRP-9） 水平及其临床意义。方法 选取2016 年10 月—2017 年10 月罗定市人民医院就诊的90 例COPD 稳定期 患者作为观察组，另选取同期于该院体检的90 例健康居民作为对照组。分别采集两组血浆标本，应用酶联 免疫吸附试验法测定两组血清CTRP-9 水平，采用肺功能仪测量两组第1 秒用力呼气容积占预计值百分比 （FEV1%pred），并分析两组评价指标的相关性。结果 观察组血清CTRP-9 水平高于对照组（P<0.05）；观 察组FEV1%pred 低于对照组（P <0.05）；Pearson 相关性分析结果显示，观察组血清CTRP-9 水平与患者肺 功能指标FEV1%pred 呈负相关（r =-0.803，P =0.004）。结论 CTRP-9 在COPD 患者血清中呈高表达，且 其表达水平与患者肺功能存在相关性。

Abstract:

Objective To investigate the serum level of C1q tumor necrosis factor-related protein 9 (CTRP- 9) in patients with chronic obstructive pulmonary disease and its clinical significance. Methods A total of 90 stable patients with chronic obstructive pulmonary disease who were present in our hospital from October 2016 to October 2017 were selected as the observation group. In the same period, 90 healthy residents who were physically examined in our hospital were selected as the control group. The serum levels of CTRP-9 were determined by enzyme-linked immunosorbent assay. Forced expiratory volume in 1st second as percentage of predicted values (FEV1%pred) of two groups were measured by spirometer, and analyzed with the serum levels of CTRP-9 for their correlation. Results The serum CTRP-9 level in the observation group was significantly higher than that in the control group (P < 0.05). The FEV1%pred of the observation group was significantly lower than that of the control group (P < 0.05). The results of the Person correlation analysis showed that the serum level of CTRP-9 was negatively correlated with FEV1%pred (r = -0.803, P = 0.004). Conclusions CTRP-9 is highly expressed in the serum of patients with chronic obstructive pulmonary disease, and the level of its expression is correlated with lung function of patients.