不同紫外线强度下健康成人维生素D 与区域骨密度的关系

Relationship between vitamin D and regional bone mineral density under different ultraviolet intensity

摘要:

目的 探究不同紫外线强度下维生素D 与区域骨密度的关系。方法 选取2015 年9 月—2016 年 9 月于青海省人民医院体检的106 例西宁、循化及玉树地区健康成人作为研究对象，根据T 值分为骨量正常 组、骨量减少组及骨量疏松组，根据维生素D 水平分为严重缺乏组、缺乏组、不足组及充足组，根据年龄划 分为青年组、中年组及老年组。对各组患者血清25- 羟基维生素D[25（OH）D]、骨密度及相关实验室指标 进行比较分析。结果 中年组男女性血清25（OH）D 水平比较，差异有统计学意义（P <0.05），随着年龄升高， 血清25（OH）D 水平呈下降趋势。不同BMD 组年龄、血压、体重、BMD 及25（OH）D 比较，差异有统 计学意义（P <0.05）。不同血清25（OH）D 水平组P、TG、LDL、HDL 及晒太阳>20 min 比较，差异有统 计学意义（P <0.05）。不同海拔的BMD、血清25（OH）D 水平比较，差异有统计学意义（P <0.05）。BMD 与25（OH）D 浓度呈负相关（r =-0.355，P <0.05）。结论 健康成人普遍处于维生素D 缺乏状态，不同海 拔骨密度及血清25（OH）D 水平有差异，应及时采取预防措施，降低骨质疏松症发病率。

Abstract:

Objective To explore the relationship between vitamin D and regional bone mineral density under different ultraviolet intensity. Methods A total of 106 healthy adults in Xining, Xunhua and Yushu areas who underwent physical examination in Qinghai People’s Hospital from September 2015 to September 2016 were selected as subjects of study. Serum 25-hydroxyl vitamin D [25(OH)D], bone mineral density and related laboratory parameters were detected. Subjects were divided into three groups (normal bone mass group, osteopenia group, and osteoporosis group) according to T value, four groups (severe deficiency group, deficiency group, insufficient group, and sufficient group) according to vitamin D level, and three groups (young group, middle-aged group and old group) according to age, respectively. Results The serum 25 (OH) D level showed a downward trend with the increase of age, and there was a significant difference in the serum 25 (OH) D level between middle-aged men and women (P < 0.05); There were significant differences in age, blood pressure, weight, BMD and 25 (OH) D among normal bone mass group, osteopenia group and osteoporosis group (P < 0.05); Phosphorus (P), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL) and sun exposure>20min had significant differences among severe deficiency group, deficiency group, insufficient group and sufficient group (P < 0.05); There was a significant difference in bone mineral density and serum 25 (OH) D level at different elevations (P < 0.05); BMD was negatively correlated with 25 (OH) D concentration (r =-0.355, P < 0.05). Conclusions Healthy adults are generally in vitamin D deficiency, and there were significant differences in bone mineral density and serum 25 (OH) D levels at different elevations. We should take preventive measures in time to reduce the incidence of osteoporosis.