巨噬细胞在骨折愈合过程中的作用

The role of macrophages in fracture healing

摘要:

巨噬细胞是重要的炎症细胞之一，因其具有强大的吞噬功能而得名。在炎症反应中，巨噬细胞吞噬组织碎片和异物在组织的愈合过程中发挥重要作用。巨噬细胞亚型M1、M2分别参与促炎和抗炎作用，M2又有4个亚型，协同作用促进损伤组织的愈合。当暴力导致骨折后释放细胞因子，如白细胞介素-4（IL-4）、IL-10、IL-13、肿瘤坏死因子-α等，招募巨噬细胞等炎症细胞到骨折处，吞噬组织碎片及异物并释放抗炎因子、血管内皮生长因子，以及其他生长因子为骨折愈合创造良好的条件。因此探讨巨噬细胞在骨折愈合过程中的作用至关重要，并为以后骨不连的研究及治疗提供新的思路。

Abstract:

Macrophages are one of the most important inflammatory cells, named for their powerful phagocytic function. Macrophages phagocytosis of tissue fragments and foreign bodies plays an important role in the process of tissue healing in inflammatory response. Macrophage subtypes M1 and M2 participated in the pro-inflammatory and anti-inflammatory effects respectively, and M2 had four subtypes to promote the healing of injured tissues. When violence causes fracture, release cytokines IL-4, IL-10, IL-13, TNF-α, etc., recruit macrophages and other inflammatory cells to the fracture site, phagocytosis of tissue fragments and foreign bodies and releasing anti-inflammatory factors, such as vascular endothelial growth factor (VEGF) and other growth factors to create good conditions for fracture healing; therefore, to explore the role of macrophages in fracture healing. The role of the healing process is very important and provides new ideas for the future research and treatment of nonunion.