PTPRS 在食管腺癌中的表达水平及临床意义

Expression levels and clinical implications of PTPRS in esophageal adenocarcinoma

摘要:

目的 探讨蛋白酪氨酸磷酸酶受体S（PTPRS）在食管腺癌组织中的表达及临床意义。方法 应 用组织芯片技术和免疫组织化学法检测71 例食管腺癌患者的癌组织、癌旁组织及食管正常黏膜中PTPRS 蛋白的表达情况，分析PTPRS 蛋白与食管腺癌患者临床病理特征和预后的关系。结果 PTPRS 蛋白在食 管腺癌组织中表达量低于食管正常黏膜组织（P <0.05）。不同临床分期、浸润深度、淋巴结转移状态、分 化程度、神经受侵及脉管瘤栓的食管腺癌患者的PTPRS 蛋白表达水平比较，差异有统计学意义（P <0.05）。 Kaplan-Meier 生存分析显示，PTPRS 低表达患者生存率低于高表达患者（P <0.05）；多因素Cox 回归分析 显示，PTPRS 为食管腺癌患者预后不良的独立危险因素[Hl ^ R=2.265，（95% CI ：1.050，4.887），P =0.037]。 结论 PTPRS 蛋白低表达与食管腺癌患者的复发和预后密切相关。PTPRS 可能是潜在的抑癌基因，在食管癌 的发生、发展中发挥重要的调控作用。

Abstract:

Objective To study the clinical significance and expression level of protein tyrosine phosphatase receptor S (PTPRS) in human esophageal adenocarcinoma tissues. Methods Clinicopathological and prognostic roles of PTPRS in 71 cases of esophageal adenocarcinoma were investigated. Paraffin embedded tissue with immunohistochemistry methods and tissue microarrays (TMAs) were adopted to exam PTPRS expression in esophageal adenocarcinoma, paired normal esophageal mucosa and adjacent tissues. Results PTPRS was significantly down-regulated in esophageal adenocarcinoma compared to normal tissues (P < 0.05). Statistical analysis revealed that PTPRS expression was significantly associated with TNM stage, invasion depth, local lymph node metastasis, tumor differentiation, nerves invaded and vascular invasion (P < 0.05). Furthermore, Kaplan-Meier survival analysis revealed that low expression of PTPRS significantly was correlated with shorter overall survival of esophageal adenocarcinoma patients (P < 0.05). Cox regression analysis confirmed PTPRS expression as an independent predictor of the overall survival of ESCC patients [Hl ^ R=2.265, (95% CI: 1.050, 4.887), P = 0.037]. Conclusions PTPRS may be a new potential tumor suppressor gene, plays an important role in tumor development and may serve as a reliable indicator for prognostic prediction in esophageal adenocarcinoma patients.