IL-33/ST2 信号通路在缺血性脑卒中的作用

The role of interleukin-33/ST2 signaling pathway in ischemic stroke

摘要:

缺血性脑卒中是临床上常见的脑血管疾病，免疫炎症反应在其发病机制中起着关键作用。IL-1 家族新成员IL-33 是Th2 型免疫反应的关键活化分子，经由IL-33/ST2 信号通路在不同的疾病和模型中发挥 促炎或抑炎效应。近年来，关于IL-33 及其信号通路在缺血性脑卒中发生、发展中的作用和作用机制的研究 越来越得到关注，被认为是缓解缺血性脑损伤后炎症反应的新型靶点。本文综述IL-33/ST2 信号通路的生成 及其在缺血性脑卒中的病理生理作用，并介绍最新的相关研究进展。

Abstract:

There is evidence that ischemic stroke is the most common type of clinical cerebrovascular disease and inflammation plays a critical role in the pathogenesis of ischemic stroke. As an inducer of Th2 immune responses, IL-33, a novel member of the IL-1 cytokine family, has pleiotropic effects on immune responses via IL- 33/ST2 signaling pathway. In recent years, IL-33 and its signaling pathway have attracted wide attention in the field of ischemic stroke pathogenesis, and it has been considered as a new target for alleviating the inflammation caused by ischemic brain injury. The generation of IL-33/ST2 signaling pathway and its physiological function in ischemic stroke were discussed, and the latest research progress was also introduced in this paper.