急性心肌梗死患者血清外连素水平及临床意义

Serum vitronectin level in patients with acute myocardial infarc-tion and its clinical significance

摘要:

目的 探讨急性心肌梗死患者血清外连素水平及其与病情严重程度和预后的关系。方法 选取 2017 年1 月—2017 年12 月衢州市人民医院收治的急性心肌梗死患者80 例作为心肌梗死组，同期该院健康者 体检的80 例作为对照组。收集两组患者的临床资料与随访资料，测定血清外连素、心肌型肌酸激酶同工酶 （CK-MB）、心肌肌钙蛋白Ⅰ（cTnI）水平。结果 心肌梗死组患者血清外连素、CK-MB 及cTnI 水平高于 对照组（P <0.05）。心肌梗死组不同冠状动脉狭窄程度患者血清外连素、CK-MB、cTnI 水平和Gensimi 积 分比较，差异有统计学意义（P <0.05）；中度和重度患者血清外连素、CK-MB、cTnI 水平和Gensimi 积分高 于轻度患者（P <0.05），重度患者血清外连素、CK-MB、cTnI 水平和Gensimi 积分高于中度患者（P <0.05）。 心肌梗死组患者血清外连素与CK-MB、cTnI 及Gensimi 积分呈正相关（P <0.05）。心血管不良事件组血清 外连素、CK-MB、cTnI 水平及Gensimi 积分高于非心血管不良事件组（P <0.05）。结论 急性心肌梗死患 者血清外连素水平升高，血清外连素水平升高程度与病情严重程度和心血管不良事件有关。

Abstract:

Objective To investigate the serum vitronectin level in patients with acute myocardial infarction and its relationship with severity and prognosis. Methods Eighty patients with acute myocardial infarction who were hospitalized were selected as the myocardial infarction group, and 80 physical examinations of the same period were selected as the control group in the Department of Cardiology from January 2017 to December 2017. The clinical data and follow-up data were collected. The serum vitronectin, CK-MB and cTnI levels were determined. Results The serum levels of vitronectin, CK-MB and cTnI in the myocardial infarction group were higher than those in the control group (P < 0.05). Comparison of serum levels of ubiquitin, CK-MB, cTnI and Gensimi scores in patients with different degrees of coronary artery stenosis was significantly different (P < 0.05); compared with the mild patients, the serum vitronectin, CK-MB, cTnI levels and Gensimi scores were elevated in the moderate and severe patients; compared with moderate patients, the serum vitronectin, CK-MB, cTnI levels and Gensimi scores were elevated in severe patients.The serum vitronectin in the myocardial infarction group was positively correlated with CK-MB, cTnI and Gensimi scores (P < 0.05). The serum vitronectin, CK-MB, cTnI levels and Gensimi scores in the cardiovascular adverse event group were higher than those in the non-cardiovascular adverse events group (P < 0.05). Conclusions The serum vitronectin level is elevated in patients with acute myocardial infarction. The level of serum vitronectin is associated with severity of the disease and cardiovascular adverse events.