海南地区妊娠期高血压疾病患者母婴HLA-DRB1基因共享率研究*

HLA-DRB1 gene frequency in maternity and infant in hypertensive disorder of pregnancy*

摘要:

Abstract:

Objective To investigate the rate of HLA-DRB1 gene sharing in maternal fetuses with pregnancy-induced hypertension (HDP) in Hainan Province. Methods A total of 50 cases of HDP and 50 healthy individuals were involved in this study. HLA-DRB1 was genotyped using the HLA Genotyping Assay Kit (PCR-SBT). Results There was no significant difference in HLA-DRB1 antigen between healthy group and HDP group (P?>?0.05). In HDP group, 0, 45 and 5 cases shared 0, 1 and 2 DR antigens, respectively. In the control group, 1, 44 and 5 cases patients shared 0, 1 and 2 DR antigens. There was no significant difference in the number of maternal and fetal antigen sharing between the two groups (P?>?0.05). Conclusions No obvious difference in rate of maternal-fetal HLA-DRB1 gene among HDP pregnant women and healthy individuals.