慢性阻塞性肺疾病合并阻塞性睡眠呼吸暂停低通气综合征与脂联素、8-异前列腺素F2α的关系*

Clinical significance of adiponectin and 8-iso prostaglandin F2α in patients with chronic obstructive pulmonary disease complicated with obstructive sleep apnea hypopnea syndrome*

摘要:

目的 探讨慢性阻塞性肺疾病（COPD）合并阻塞性睡眠呼吸暂停低通气综合征（OSAHS）（简称重叠综合征，OS）与血清脂联素、8-异前列腺素F2α的关系。方法 选取海南省人民医院COPD患者80例 （COPD组），OS患者40例（OS组）共120例患者，收集患者年龄、性别、吸烟、体重指数（BMI）、第一秒钟用力呼气量与用力肺活量比值（FEV1%）等基本情况。酶联免疫吸附试验（ELISA）检测两组患者血清脂联素、8-异前列腺素F2α水平；多重线性回归分别分析OS与脂联素、8-异前列腺素F2α的关系。结果 两组患者年龄、性别、吸烟、血压、血糖、血脂差异无统计学意义（P?>0.05）；OS组患者BMI和8-异前列腺素F2α高于COPD组（P?<0.05）；OS组患者FEV1%和脂联素低于COPD组（P?<0.05）。多重线性回归调整年龄、性别、BMI、FEV1%等混杂因素后，OS与脂联素有负向影响，与8-异前列腺素F2α有正向影响（P?<0.05）。结论 OS较单纯COPD抗炎作用减退，抗胰岛素抵抗和抗动脉粥样硬化作用减退，氧化应激作用增强，提示COPD合并OSAHS增加COPD患者多种代谢紊乱和心脑血管疾病的风险。

Abstract:

Objective To investigate clinical significance of serum adiponectin and 8-iso prostaglandin F2α in patients with chronic obstructive pulmonary disease (COPD) complicated with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods A total of 120 patients were enrolled in this study. The patients were divided into COPD group (n?=?80 cases) and OS group (COPD combined with OSAHS, n?=?40 cases). The age, gender, smoking, body mass index (BMI), forced vital capacity rate of one second (FEV1%/FVC) were recorded. Serum levels of adiponectin and 8-iso prostaglandin F2α were measured by ELISA. Results There were no significant differences in age, gender, smoking, blood pressure, blood glucose and blood lipid between the two groups (P?>?0.05). Compared with patients with COPD, OS patients experienced increase in BMI and 8-iso prostaglandin F2α while decrease in FEV1%/FVC and adiponectin (P?