内皮细胞特异性分子-1水平与阿尔茨海默病患者抑郁的相关性

Association of serum endocellular-specific molecule-1 levels with depression in Alzheimer’s disease*

摘要:

目的 探讨内皮细胞特异性分子-1（ESM-1）水平和阿尔茨海默病（AD）患者抑郁的相关性。方法 采用ELISA检测26例伴抑郁的AD患者（研究组）、29例不伴抑郁的AD患者（对照组）及29例健康志愿者（正常组）的ESM-1水平与抑郁症状。采用简易精神状态检查表（MMSE）和老年忧郁量表简明版（SGDS）评估受试者抑郁症状和认知功能。结果 研究组ESM-1水平低于对照组和正常组，差异有统计学意义（P?<0.05）。ESM-1水平与SGDS评分呈负相关（r?=-0.254，P?=0.009），与MMSE评分无相关性（r?=0.120，P?=0.378）。结论 ESM-1与AD患者抑郁相关，能够作为AD患者抑郁程度的生物指标。

Abstract:

Objective To explore association of endocellular-specific molecule-1 (ESM-1) levels with depression in Alzheimer’s disease (AD). Methods A total of 26 AD patients with depression, 29 AD patients without depression, and 29 healthy controls were involved in this study. Serum ESM-1 were measured using an enzyme-linked immunosorbent assay kit. The Mini-Mental State Examination-Korean version (MMSE-KC) and the Korean version of the Geriatric Depression Scale-Short Form (SGDS-K) were used to evaluate cognitive function and depressive symptoms, respectively. Results Serum ESM-1 were significantly lowered in AD patients with depression than that in AD patients without depression or healthy controls (P?