25-羟维生素D及骨保护素与慢性心力衰竭的相关性研究

Association study of serum 25-hydroxyvitamin D and osteoprotegerin with chronic heart failure

摘要:

目的 检测慢性心力衰竭患者25-羟维生素D 25（OH）D及骨保护素（OPG）水平，分析两者与慢性心力衰竭的相关性。方法 148例慢性心力衰竭患者依据心功能不同分为心功能Ⅱ、Ⅲ及Ⅳ级组，选取同期入院但无心力衰竭的患者42例为对照组，检测所有研究对象肝肾功能、血脂、血糖、碱性磷酸酶（ALP）、25（OH）D、OPG等，心脏超声检查左室舒张末期容积（LVDD）及左室射血分数（LVEF），分析25（OH）D及OPG与其他指标的相关性。结果 心力衰竭患者25（OH）D水平降低，ALP及OPG水平较对照组升高，心功能Ⅳ级患者25（OH）D水平最低，与心功能Ⅱ级及对照组比较，心功能Ⅲ、Ⅳ级患者OPG水平升高，LVDD增大，LVEF降低，差异有统计学意义（P?<0.05）。相关性分析发现25（OH）D与NT-proBNP呈负相关；OPG与LVEF呈负相关，与NT-proBNP及ALP呈正相关（P?<0.05）。结论 慢性心力衰竭患者OPG高表达，25（OH）D低表达，两者与心力衰竭有一定相关性。

Abstract:

Objective To analyze the association of 25 hydroxyvitamin D and osteoprotegerin with chronic heart failure. Methods Totally 148 patients with chronic heart failure were divided into group II, grade III and grade IV according to cardiac function. 42 cases of patients without heart failure were selected as control group. The liver and kidney function, blood lipid, blood glucose, alkaline phosphatase, levels of 25-hydroxyvitamin D and osteoprotegerin were recorded in all subjects. The left ventricular end diastolic volume and left ventricular ejection fraction were obtained by heart ultrasonography. Results A total of 25 hydroxyvitamin D was significantly lowered while alkaline phosphatase and osteoprotegerin levels were highered in patients with heart failure than those in patients without heart failure. The level of 25 hydroxyvitamin D was the lowest in patients with grade IV cardiac function (P?