甲状腺功能异常者摄碘率与血液中NIS-Ag甲状腺过氧化物酶的相关性研究*

Correlation between iodine uptake rate and NIS-Ag thyroid peroxidase in blood of patients with thyroid dysfunction*

摘要:

目的 探讨甲状腺功能减退（甲减）和甲状腺功能亢进（甲亢）患者治疗前后摄碘率（RAIU）与甲状腺钠/碘同向转运体抗原（NIS-Ag）、甲状腺过氧化物酶（TPO）含量变化的相关性。方法 选取2015年2月— 2016年8月濮阳市安阳地区医院36例健康体检人员和108例甲状腺疾病就诊患者做为研究对象。电化学发光法检测血清中游离三碘甲状腺素原氨酸（FT3）、游离甲状腺素原氨酸（FT4）和促甲状腺激素（TSH）含量。用甲状腺摄碘功能仪分别检测各组的3?h RAIU、24?h RAIU，用酶联免疫吸附试验测定血浆中NIS-Ag、TPO含量，比较各组别RAIU、NIS-Ag、TPO含量，并分析患者药物治疗前后RAIU与NIS-Ag、TPO相关性。结果 FT3、FT4、TSH含量，除甲减摄碘率增高组和减低组之间比较无差异外，其余各组含量比较，差异有统计学意义（均P?<0.05）。甲减摄碘率增高组和减低组FT3、FT4含量最低，TSH最高；甲亢组FT3、FT4含量最高，TSH 最低。各组治疗前3?h RAIU、24?h RAIU、NIS-Ag及TPO含量比较，差异有统计学意义（P?<0.05）。24?h RAIU、 3?h RAIU、NIS-Ag及TPO在甲减甲状腺摄碘率减低组中最低，而在甲亢组中最高。各患病组3?h RAIU、24?h RAIU与NIS-Ag、TPO均呈正相关，差异有统计学意义（P?<0.05），但在正常组该指标间无相关性（P?>0.05）。各组治疗后24?h RAIU、3?h RAIU、NIS-Ag及TPO值均较治疗前降低，差异有统计学意义（P?<0.05）。各患病组治疗后3?h RAIU、24?h RAIU与NIS-Ag、TPO均呈正相关，差异有统计学意义（P?<0.05）。结论 甲减患者和甲亢患者RAIU与NIS-Ag、TPO存在正相关性；药物治疗能降低RAIU、NIS-Ag及TPO。

Abstract:

Objective To investigate the iodine uptake rate (RAIU) and thyroid sodium/iodine symporter antigen (NIS-Ag) and thyroid peroxidase (TPO) before and after treatment in patients with hypothyroidism (hypothyroidism) and hyperthyroidism (hyperthyroidism). Methods From February 2015 to August 2016, 36 healthy medical examiners and 108 thyroid disease patients from Anyang District Hospital were selected as subjects. The levels of free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) in serum were detected by electrochemiluminescence. The thyroid iodine function meter was used to detect the 3?h RAIU and 24?h RAIU of each group. The content of NIS-Ag and TPO in plasma was determined by enzyme-linked immunosorbent assay. The correlation between RAIU and NIS-Ag and TPO content in each group was analyzed. Sex, and analyze whether there is any difference or correlation between RAIU and NIS-Ag and TPO levels in patients before and after drug treatment. Results The levels of thyroid function FT3, FT4, and TSH were not significantly different between the group with the decrease of iodine reduction and the group with the reduction of iodine. The difference was statistically significant (P?< 0.05). The levels of FT3 and FT4 were the lowest and the TSH was the highest in the iodine reduction group and the reduction group. The acetaminophen group had the highest FT3 and FT4 content and the lowest TSH. There were significant differences in the levels of RAIU, 24?h RAIU, NIS-Ag and TPO between the three groups before treatment (P??0.05). The RAIU, 3h RAIU, NIS-Ag and TPO values of the 24 h after treatment were lower than those before treatment, and the difference was statistically significant (P?< 0.05). RAIU and 24?h RAIU were positively correlated with NIS-Ag and TPO at 3?h after treatment in each diseased group, and the difference was statistically significant (P?