脂联素、抵抗素及瘦素在生殖领域的研究进展

Research progress of adiponectin, resistin and leptin in reproductive field

摘要:

脂联素是胰岛素和能量平衡的上调因子。抵抗素可能对脂肪转化有抑制作用，可作为脂肪生成 和脂肪组织的反馈调节器。瘦素能调节食物摄入、肝脏葡萄糖生成及促性腺激素分泌，是脂肪生成抑制剂和 免疫反应调节剂。脂联素诱导体外受精的超排卵，高瘦素可能会干扰发育成熟的卵母细胞。多囊卵巢综合征 患者血清脂联素、抵抗素及瘦素水平是否降低尚无统一结论。而妊娠期糖尿病及子痫前期血清瘦素水平升高， 生长受限胎儿脐血中脂联素、瘦素水平降低，妊娠期糖尿病患者脐血及母血抵抗素水平结论不一。

Abstract:

Adiponectin is an up-regulating factor for the balance of insulin and energy. Resistin may inhibit fat transformation and act as a feedback regulator of fat formation and adipose tissue. Leptin mainly regulates food intake, liver glucose production, gonadotropin secretion, adipose tissue lipogenesis inhibition and immune response regulation. It has been recently found that hyperovulation is induced by adiponectin, and high leptin may interfere with mature oocyte. There is no consistent conclusion of serum levels of adiponectin, resistin and leptin are decreased in patients with polycystic ovary syndrome. The levels of adiponectin and leptin in fetal growth limited umbilical blood are decreased, and leptin levels are increased in gestational diabetes and preeclampsia. Conclusions of resistin in umbilical cord blood and maternal blood of gestational diabetes mellitus patients are different.