抗体分型检测对幽门螺杆菌感染的诊断价值

Clinical value of antibody typing for diagnosis of helicobacter pylori infection

摘要:

目的 探讨幽门螺杆菌（Hp）抗体分型检测在诊断Hp 感染中的价值。方法 选取2010 年 7 ～ 12 月在山东大学附属济南市中心医院进行抗体分型受试者462 例，根据抗体分型分为Ⅰ型202 例（Ⅰ型组） 和Ⅱ型（Ⅱ型组）104 例和对照组156 例。记录各组是否患有Hp 感染相关性疾病，抗体检测前后1 周行尿素 呼气试验（UBT）。结果 共462 例受试者进行抗体分型检测，Hp 总感染率为66.2%。Ⅰ型、Ⅱ型感染率分 别为43.7% 和22.5%，最常见抗体分型为CagA、VacA、UreA 及UreB 均为阳性；年龄、Hp 相关性疾病、阑 尾炎及饮酒为Hp 感染的独立危险因素（P <0.05）。I 型感染患者中UBT 阳性率高于Ⅱ型（P <0.05）；Hp 抗 体分型与UBT 总一致率为84.53%，阳性、阴性符合率分别为80.55% 和86.88%。结论 该地区Hp 感染率偏高， 高龄、Hp 相关性疾病、阑尾炎及饮酒为Hp 感染高危因素。UBT 与抗体分型联合有助于诊断Hp 感染并分型， 进一步提高临床诊断Hp 的水平。

Abstract:

Objective To investigate the rate of helicobacter pylori (Hp) infection by using antibody typing detection, and to analyze the value of Hp antibody type in diagnose of Hp infection and its risk factors. Methods The patients accepted Hp antibody typing from July 2017 to Dec 2017 were selected from Jinan Central Hospital affiliated to Shandong University. According to Hp antibody type, all patients were divided into 2 groups, type I and type II. Whether or not with Hp related diseases were recorded, and UBT (Urea Breath Test UBT) were performed one week before or after Hp antibody type detection. Results In total, there were 462 patients accepted Hp antibody type detection, and the total infection rate was 66.2%; 43.7% of patients were defined type I and 22.5% were defined type II. The most common antibody type cagA, vacA, ureA and ureB were positive. Age, Hp related diseases, appendicitis and drinking were statistically different among the three groups, which were independent risk factors for the Hp infection (P < 0.05). UBT positive rate of patients with type I were higher than that of type II (P < 0.05). The positive coincidence rate of UBT and antibody typing was 80.55%, and the negative coincidence rate was 86.88%, and the total coincidence rate was 84.53%. Conclusions The Hp infection rate in this area was high. Age, Hp related diseases, appendicitis and drinking were the high risk factors of the Hp infection. UBT combine with antibody type can be useful in diagnosing and classifying Hp Infection.