雷珠单抗玻璃体联合巩膜睫状体光凝治疗 新生血管性青光眼的疗效分析

Efficacy of intravitreal injection of razumab combined with scleral ciliary body photocoagulation in the treatment of neovascular glaucoma

摘要:

目的 探讨雷珠单抗玻璃体腔注射联合经巩膜睫状体光凝+ 全视网膜光凝治疗新生血管性青 光眼的疗效。方法 选取南通大学附属医院2015 年1 月—2017 年9 月收治的新生血管性青光眼患者80 例， 按照随机数字表法分为观察组和对照组，各40 例。观察组采用雷珠单抗玻璃体腔注射联合经巩膜睫状体光 凝+ 全视网膜光凝治疗，对照组仅采用经巩膜睫状体光凝+ 全视网膜光凝治疗。结果 两组术前、术后7 天、术后1 和6 个月眼压比较，结果显示：①不同时间点患者的眼压有差异（F =23.5421，P =0.000）；②两 组患者术后的眼压有差异（F =18.432，P =0.000），观察组术后眼压较对照组患者偏低，改善明显；③两组 患者眼压的变化趋势有差异（F =84.2145，P =0.000）。两组术后并发症比较，差异无统计学意义（P >0.05）。 结论 雷珠单抗玻璃体腔注射联合经巩膜睫状体光凝+ 全视网膜光凝治疗新生血管性青光眼的效果显著，值 得推广应用。

Abstract:

Objective To investigate the effect of intravitreal injection of rezumab combined with scleral ciliary body photocoagulation and total retinal photocoagulation on the treatment of neovascular glaucoma. Methods Totally 80 cases (80 eyes) of neovascular glaucoma admitted to our hospital from October 2014 to October 2016 were selected. They were randomly divided into observation group (40 cases) and control group (40 cases). The observation group was treated by intravitreal injection of rezumab combined with scleral ciliary body photocoagulation and total retinal photocoagulation, while the control group was treated only by scleral ciliary photocoagulation combined with whole retinal photocoagulation. Results The results showed that there were significant differences in intraocular pressure between the two groups at different time points (F = 23.5421, P = 0.000); there were significant differences in intraocular pressure between the observation group and the control group (F = 18.432, P = 0.000), and observation group has lower postoperative intraocular pressure and better curative effect than control group; there were significant differences in trends of intraocular pressure between two groups (F = 84.2145, P = 0.000); there was no statistical difference in postoperative complications between two groups (P > 0.05). Conclusions The efficacy of intravitreal injection of rezumab combined with scleral ciliary body photocoagulation and whole retinal photocoagulation in the treatment of neovascular glaucoma is significant and this treatment is worthy of popularization and application.