血清网膜素-1 与糖尿病周围神经病变的相关性

Correlation between serum omentin-1 and diabetic peripheral neuropathy

摘要:

目的 探讨血清网膜素-1 与糖尿病周围神经病变（DPN）的相关性。方法 选取2016 年6 月— 2017 年10 月海南省第三人民医院收治的100 例2 型糖尿病患者，根据是否合并周围神经病变，将其分为 DPN 和无DPN 组，各50 例。另选取同期该院健康体检者50 例作为对照组。测量各组的体重、身高、腰围、 臀围，计算体重指数（BMI）及腰臀比（WHR）；检测空腹血糖（FPG）、空腹胰岛素（Fins）、糖化血红蛋白 （HbA1C）、24 h 尿白蛋白排泄率（24 hUAER）、胱抑素C（Cys-C）、胆固醇（TC）、甘油三酯（TG）、高密 度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）及血清网膜素-1 水平，计算胰岛素抵抗指数（HOMA-IR） 和胰岛β 细胞功能指数（HOMA-β）。结果 各组BMI、WHR、TG、Fins、FPG、HOMA-IR、HbAlc、 血清网膜素-1、HDL-C 及HOMA-β 比较，差异有统计学意义（P <0.05），DPN 组和无DPN 组患者血 清网膜素-1 水平均低于对照组（P <0.05），DPN 组患者血清网膜素-1 水平均低于无DPN 组（P <0.05）。 血清网膜素-1 水平与HOMA-β 呈正相关（r =0.496，P =0.000），与病程、WHR、TG、Cys-C、FPG、 HbA1c 及24 hUAER 呈负相关（r =-0.323、-0.127、-0.173、-0.326、-0.449、-0.328 和-0.331，P =0.009、 0.013、0.035、0.000、0.000、0.000 和0.023）。Logistic 回归分析结果表明血清网膜素-1 是影响DPN 发生的 危险因素[Ol ^ R=1.011（95%CI ：1.003，1.019），P =0.013]。结论 DPN 的发生、发展可能与血清网膜素-1 水 平降低有关。

Abstract:

Objective To investigate the relationship between serum omentin-1 and diabetic peripheral neuropathy. Methods Totally 100 patients with type 2 diabetes mellitus (T2DM) admitted to our hospital from June 2016 to October 2017 were divided into non-diabetic peripheral neuropathy (Non-DPN) group and diabetic peripheral neuropathy (DPN) group, 50 patients of each group. Another 50 healthy subjects were selected as the control group. The body mass, height, waist circumference and hip circumference of each group were measured and body mass index (BMI) and waist-hip ratio (WHR) were calculated. The levels of fasting blood glucose (FPG), fasting insulin (Fins), HbA1C, 24 hours urinary albumin (Cys-C), cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C) and serum omentin-1 were detcected. The calculated insulin resistance index (HOMA-IR) and pancreatic β-cell function index (HOMA-β) were calculated. Results There were significant differences in BMI, WHR, TG, Fins, FPG, HOMA-IR, HbAlc, serum omenin-1, HDL-C and HOMA-beta among groups (P < 0.05). Serum retinal-1 levels in patients with DPN and Non-DPN were higher than those in the control group (P < 0.05). Serum retinal-1 levels in the DPN group were lower than those in the Non-DPN group (P < 0.05). The level of serum omentin-1 was positively correlated with HOMA-β (P < 0.05), and negatively correlated with duration, WHR, TG, Cys-C, FPG, HbA1c and 24hUAER (P < 0.05). Logistic regression analysis showed that serum omentin-1 is a risk factor of diabetic peripheral neuropathy (Ol ^ R=1.011, 95% CI: 1.003, 1.019). Conclusions The decrease of serum omentin-1 level may be involved in the development of diabetic peripheral neuropathy.