催产素受体在肠易激综合征患者中的表达研究*

Role of Oxytocin Receptor in patients with Irritable Bowel Syndrome*

摘要:

目的 探讨肠易激综合征（IBS）患者结肠黏膜催产素受体（OTR）的表达与IBS亚型、症状严重程度、伴随精神障碍的相关性。方法 选取长治医学院附属和平医院41例受试者，其中，27例IBS患者（实验组）和14例健康者（对照组），根据IBS患者粪便性状又将实验组分为IBS腹泻型组（IBS-D组）和IBS不定型组（IBS-U组）。收集符合罗马Ⅳ标准的IBS患者和健康受试者的结肠黏膜样本，免疫组织化学法检测OTR的表达。结果 实验组与对照组年龄、性别差异无统计学意义（P?>0.05）。IBS-U组与IBS-D组年龄、性别、病情严重程度调查表（IBS-SSS）评分、两组精神心理状态差异无统计学意义（P?>0.05）。实验组OTR表达与对照组比较，差异有统计学意义（P?<0.05）；对照组、IBS-D组及IBS-U组OTR表达差异有统计学意义（P?<0.05）。OTR表达与IBS患者病情严重度调查表（IBS-SSS）评分、精神心理状态无相关（P?>0.05）结论 OTR与IBS有一定关联。

Abstract:

Objective To investigate clinical significance of oxytocin receptor (OTR) expression in colon mucosa of patients with irritable bowel syndrome (IBS). Methods Colonic mucosal samples from 27 IBS patients and 14 healthy subjects were collected. IBS patients were sub-grouped into IBS-D group and IBS-U group. Expression of OTR were measured by immunohistochemistry. Results There was no significant difference in age, sex, IBS-SSS score and psychological status between the two groups (P?>?0.05). OTR expression was significantly higher in IBS group than that in the normal control group. Expression of OTR was significantly altered in IBS-D group and IBS-U group. No obvious correlation between OTR expression and IBS-SSS score or psychological status was identified (P?>?0. 05). Conclusions Increase in OTR expression in IBS patients does not correlate with IBS severity or psychological status.