脑梗死患者血清CXCL-16、GDF-15、PLA2水平变化及意义*

Clinical significance of serum CXCL-16, GDF-15 and PLA2 in patients with cerebral infarction*

摘要:

目的 研究脑梗死患者的血清CXC趋化因子16（CXCL-16）、血清生长分化因子15（GDF-15）、脂蛋白相关磷脂酶A2（PLA2）的水平变化及对脑梗死患者临床诊治的指导意义。方法 选取2016年6月— 2017年6月沧州市中心医院98例脑梗死患者为观察组，同期该院进行体检的50例健康志愿者作为对照组。所有受试者于入院时抽血检测各组的CXCL-16、GDF-15、PLA2、C反应蛋白（CRP）水平，综合评价脑梗死患者各项指标的水平变化及对临床诊断的意义。结果 ①观察组患者的CXCL-16、GDF-15、PLA2、CRP水平与对照组比较，差异有统计学意义（P?<0.05）。②将观察组患者按美国国立卫生院神经功能缺损评分（NIHSS）分组，患者的CXCL16、GDF-15、PLA2水平随着NIHSS分值的增加而升高，组间比较，差异有统计学意义（P?< 0.05），而各组间的CRP水平差异无统计学意义（P?>0.05）。③将患者按病灶大小分组，患者的CXCL16、GDF-15、 PLA2水平随病灶的增大而升高（P?<0.05），而各组间的CRP水平差异无统计学意义（P?>0.05）。④观察组患者治疗后出院时的CXCL-16、GDF-15、PLA2、CRP水平与对照组比较，差异无统计学意义（P?>0.05），观察组患者的这些指标水平降至正常水平。结论 CXCL-16、GDF-15、PLA2水平随患者病情程度的变化而改变，可作为预测脑梗死患者发病、病情评估及判断预后的生物学标志物。

Abstract:

Objective To study the clinical significance of serum CXC-16, Growth differentiation factor serum-15 (GDF-15), lipoprotein associated phospholipase A2 (PLA2) level in patients with cerebral infarction. Methods A total of 98 patients with cerebral infarction who were admitted in our hospital during June 2016 to June-2017 were enrolled in the observation group, and 50 healthy volunteers were selected as the control group. Serum levels of CXCL16, GDF-15, PLA2, C-reactive protein, and comprehensive evaluation index were recorded. Results The levels of CXCL-16, GDF-15, PLA2 and CRP were higher significantly in the observation group than those in the control group (P??0.05). Conclusions The levels of CXCL-16, GDF-15 and PLA2 may be a reliable biomarker for diagnosis and prognosis.