全髋关节置换术联合生物制剂治疗髋骨关节炎的效果及对S100A12、基质金属蛋白酶-13 水平的影响

Therapeutic effect of biologics in patients with hip osteoarthritis

摘要:

Abstract:

Objective To observe the therapeutic effect of biological agents in the treatment of hip osteoarthritis patients undergoing total hip arthroplasty (THA). Methods A total of 128 patients with HOA who were admitted into our hospital from June 2016 to December 2017 were randomly divided into observation group and control group. All patients were given THA combined with routine treatment. The observation group was given additional biologics. The pain score, Harris score, serum CRP, IL-18, S100A12 and MMP-13 levels were observed before and after treatment. The imaging K-L classification and adverse reactions were evaluated before and after treatment. Results There was no significant difference in blood volume, operation time or postoperative drainage volume between the two groups (P?>?0.05). Pain score decreased while the Harris score increased significantly after 12 weeks of treatment when compared with those prior to any treatments (P?