GCH1 基因、BH4 对疼痛的作用机制研究进展

Advances in GCH1 gene and BH4 in patients with pain

摘要:

疼痛是人类日常生活中常见的一种机体反应。按疼痛持续时间可分为急性疼痛和慢性疼痛。急 性疼痛常为某些急性损伤的防御反应；而慢性疼痛的发生为多因素作用，其具体机制尚不明确。生物遗传机 制可能是导致慢性疼痛的关键因素。GTP 环氢化酶1 基因和四氢生物蝶呤在疼痛发病机制中发挥重要作用， 对阐明疼痛遗传机制和潜在治疗策略有重要的意义。

Abstract:

Pain is a common body reaction in human daily life. According to the duration of pain, it can be divided into acute pain and chronic pain. Acute pain is often a defensive response to certain acute injuries, and the occurrence of chronic pain is multifactorial, and the specific mechanism is unclear. The persistence of pain suggests that biological genetic mechanisms may be a key factor in causing chronic pain. Recent studies suggest that GTP cyclohydrogenase 1 (GCH1) gene and tetrahydrobiopterin (BH4) play an important role in the pathogenesis of pain and are important for elucidating the genetic mechanisms of pain and potential therapeutic strategies.