新生儿与孕母维生素D 水平的相关性分析

Correlation analysis of vitamin D between newborns and their mothers

摘要:

目的 分析新生儿与孕母维生素D 水平的相关性。方法 选取2017 年11 月—2019 年1 月哈 尔滨医科大学附属第一医院待产的孕妇及其娩出新生儿各80 例。分别测定孕母产前静脉血及新生儿出生后 72 h 内静脉血25 羟维生素D[25（OH）D] 水平。结果 新生儿25（OH）D 平均为（13.96±6.09）ng/ml， 其中47 例（58.75%）存在维生素D 缺乏，22 例（27.50%）存在维生素D 不足，11 例（13.75%）维生素D 水 平适宜；孕母产前25（OH）D 平均为（14.54±7.17）ng/ml。新生儿25（OH）D 水平在胎龄、分娩方式、 性别方面比较，差异无统计学意义（P >0.05），但在出生体重、季节方面比较，差异有统计学意义（P <0.05）， 夏秋季节高于冬春季节。新生儿25（OH）D 水平和孕母孕晚期25（OH）D 水平呈正相关（r s =0.824， P =0.000）。以孕母25（OH）D 水平4.75 ng/ml 为界值，对应的敏感性为97.9%（95% CI ：0.607，0.838），特 异性为71.4%（95% CI ：0.655，0.981）。结论 黑龙江地区新生儿维生素D 水平偏低，与孕母维生素D 水平 成正相关；与出生体重、季节存在相关性，测定孕母维生素D 水平，可帮助判断新生儿维生素D 营养状态。

Abstract:

Objective To analyze the correlation between neonatal and maternal vitamin D levels. Methods To measure vitamin D levels of 80 newborns within 72h after birth and their mothers within a week before delivery, from November 2017 to January 2019 in Heilongjiang province. Results Neonatal average vitamin D level is (13.96±6.09) ng/ml, the rate of vitamin D insufficiency is 27.50%, and the rate of vitamin D deficiency is 58.75%; maternal average vitamin D level is (14.54±7.17) ng/ml; neonatal vitamin D level is related with birth weight and season (P < 0.05), rather than gestational age, delivery mode and gender (P > 0.05); Neonatal 25 (OH) D level is positively correlated with maternal vitamin D level (r s =0.824, P = 0.000). The sensitivity and specificity to predict neonatal vitamin D deficiency when maternal 25 (OH) D level lower than 4.75ng/ml were 97.9% (95% CI: 0.607, 0.838) and 71.4% (95% CI: 0.655, 0.981). Conclusions Neonatal vitamin D level is low in Heilongjiang province, it is correlated with maternal vitamin D level, as well as birth weight and season. Maternal vitamin D levels can help predict the levels of newborns.