多索茶碱对慢性阻塞性肺疾病 急性加重期的疗效分析

Involvement of JAK/STAT pathway in chronic obstructive pulmonary disease in acute exacerbation period and effect of doxofylline

摘要:

目的 通过分析多索茶碱对慢性阻塞性肺疾病（COPD）急性加重期的疗效及对JAK/STAT 通路蛋白表达的影响，为临床治疗提供参考。方法 选取2015 年1 月—2017 年7 月琼海市中医院收治 的COPD 急性加重期患者，分析患者多索茶碱的疗效及治疗前后血清中JAK/STAT 通路蛋白的表达变化。 结果 COPD 急性加重期患者JAK1、JAK2、STAT1 和STAT2 蛋白相对表达量较对照组高（P <0.05）； COPD 急性加重期组治疗后FEV1、FVC、FEV1/FVC 及PaO2 较治疗前升高（P <0.05），PaCO2 较治疗前降低 （P <0.05）；COPD 急性加重期患者治疗前JAK1、JAK2、STAT1 和STAT2 蛋白相对表达量高于治疗后（P <0.05）。 结论 多索茶碱对COPD 急性加重期患者肺功能有明显的改善作用，且对JAK/STAT 通路蛋白表达有明显的 下调作用。

Abstract:

Objective To analyze the JAK/STAT pathway in chronic obstructive pulmonary disease in acute exacerbation period and the effect of doxofylline. Methods The clinical data of patients with acute exacerbation of chronic obstructive pulmonary disease during the period from January 2015 to July 2017 in Qionghai Hospital of Traditional Chinese Medicine were analyzed. The expression of JAK/STAT pathway proteins in patients before and after doxofylline treatment was detected. Results Compared with the control group, the expression of JAK1, JAK2, STAT1 and STAT2 increased significantly in the patients with acute exacerbation of chronic obstructive pulmonary disease (P < 0.05).The above-mentioned protein expression in high-grade patients was significantly higher than that in low-grade patients. (P < 0.05). After doxofylline treatment, the EFV1, FVC, EFV1/FVC and PaO2 were significantly increased, while JAK1, JAK2, STAT2, STAT1 and PaCO2 decreased significantly(P < 0.05). Conclusions Doxofylline significantly improves lung function in patients with acute exacerbation of chronic obstructive pulmonary disease and has a significant down-regulation effect on JAK/STAT pathway protein expression.