5-羟色胺在消化系统中的作用研究进展*

Research progress of serotonin in digestive system*

摘要:

5-羟色胺（5-HT）是一种广泛分布于哺乳动物组织内且高度保守的神经信号传导物质，在大脑皮质及神经突触中含量特别丰富，并作为抑制性神经递质发挥作用，而外周组织中的5-HT则参与了肌肉收缩、血压调控、血小板聚集等众多生理调节过程。近年来研究发现除了中枢及外周神经系统，消化系统中也有5-HT的广泛表达，并在消化系统各器官的生理、病理过程中起着重要的调控作用，然而却鲜少有学者进行系统的总结。该文将综述5-HT在消化系统中的表达变化、调控机制及相关研究进展，为后期研究消化系统疾病与神经内分泌关系提供依据，为治疗消化系统相关疾病提供新的方向及治疗靶点。

Abstract:

Serotonin (5-HT) is a highly conserved neurotransmitter and widely expresses in various tissues of mammals. Extensive expression of 5-HT in cerebral cortex and synapses acts as an inhibitory neurotransmitter. 5-HT in peripheral tissues involves in many physiological processes such as muscle contraction, blood pressure regulation and platelet aggregation. Recently, researchers have found that in addition to the central and peripheral nervous system, 5-HT was widely expressed in the digestive system and played an important role in the physiological and pathological processes of digestive system. This review intends to explore the role of 5-HT in digestive patho-physiology and regulatory mechanism as well as 5-HT-based therapeutics for the treatment of digestive diseases.