Abstract:Objective To explore the effect of coping strategy on sleep status and quality of life in postmenopausal women. Methods During October 2017 to September 2018, 600 cases of menopausal transitional women aging from 40 and 60 years old in Dandong City, Liaoning Province were selected. Patients were divided into positive coping strategy group and passive coping strategy group. The Simple Coping Style Questionnaire (SCSQ), the Pittsburgh Sleep Quality Index (PSQI), and the Menopause-Specific Quality of Life (MENQOL) were used. Results Average score of SCSQ in positive and passive group was (1.615?±?0.577) and (1.380?±?0.678), respectively. Average score of PSQI and MENQOL was (6.820?±?3.575) and (57.470?±?38.790), respectively. Sleep quality was negatively correlated with positive coping strategy (r?=?-0.432, P?=?0.000) and positively correlated with positive coping strategy (r?=?0.393, P?=?0.000). The postmenopausal quality of life score was negatively correlated with positive coping strategy (r?=?-0.516, P?=?0.000) and positively correlated with negative coping strategy (r?= 0.446, P?= 0.000). Sleep quality scores were positively correlated with menopausal quality of life scores (r?=?0.593, P?=?0.000). Sleep status could not only directly affect the quality of menopausal life in menopausal transition women, but also indirectly affect the quality of menopausal life through the mediation of coping strategy, and the mediating effect accounted for 31.06% (0.250/0.805) of the total effect. Conclusion Coping strategy partially mediates sleep status and quality of life in postmenopausal women.