人源肿瘤组织异种移植在脑胶质瘤中的应用进展

Application and development of PDX model in glioma

摘要:

脑胶质瘤是最常见的中枢神经系统原发性恶性肿瘤，目前治疗的标准方案包括手术切除，其次 是放化疗。但这些积极的治疗方案，患者平均生存期低，因而新的治疗策略显得尤为重要。人源肿瘤组织异 种移植（PDX）模型保存肿瘤细胞的原始微环境，继承原发肿瘤的所有分子生物学特性并保留肿瘤异质性， 更接近人体内环境。因此在基础医学研究领域存在较高的研究价值。该文就PDX 模型的复制、PDX 模型在 脑胶质瘤中的应用及其相关研究进展、PDX 模型的局限性和展望进行综述。

Abstract:

Glioma is the most common primary malignant tumor of the central nervous system. Currently, standard protocols include surgical excision followed by radiotherapy and chemotherapy. Despite this existing aggressive treatment, the average survival of patients is still at a low level. Therefore, a new treatment strategy is required. Patient derived xenograft (PDX) model preserves the original microenvironment of cancer cells, inherits all the molecular biological characteristics of primary tumors and preserves the heterogeneity of tumors. It is similar to the human internal environment and has high research value in the field of basic medicine. In this paper, the author studies establishment of PDX model, application of PDX model in glioma and progress of related research, limitations as well as prospects of PDX model.